PYRUVIC ACID (ACETYLFORMIC ACID)

PYRUVIC ACID

PRODUCT IDENTIFICATION

CAS NO.

127-17-3; 1892-67-7

PYRUVIC ACID

EINECS NO. 204-824-3

FORMULA CH₃COCOOH

MOL WT. 88.06

H.S. CODE 2918.30

TOXICITY

SYNONYMS 2-Oxopropanoic acid; Acetylformic acid;

alpha-Ketopropionic acid; 2-Ketopropionic Acid; Pyroracemic acid;

DERIVATION

CLASSIFICATION

alpha Keto-ACID /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

clear to yellow liquid,

MELTING POINT

11 - 12 C

BOILING POINT

165 C

SPECIFIC GRAVITY 1.26 - 1.27

SOLUBILITY IN WATER miscible (miscible with alcohol, ether)

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS Health: 3; Flammability: 2; Reactivity: 0

REFRACTIVE INDEX

FLASH POINT

82 C

STABILITY Stable under ordinary conditions. Air and light sensitive

APPLICATIONS

Pyruvic acid is a low mole weight alpha keto acid (ketone along with carboxylic acid). It contains a ketone bond on the carbon atom next to the acid group. If the ketone is on the second carbon next to the acid group, it is called beta-keto acid.

Members of alpha-keto acid

alpha-keto acid	CAS RN
Pyruvic acid	127-17-3
Phenylpyruvic acid	156-06-9
4-Hydroxyphenylpyruvic acid	156-39-8
Glyoxylic acid	298-12-4
alpha-Ketoglutaric acid	328-50-7
Oxalacetic acid	328-42-7
Indol-3-ylpyruvic acid	392-12-1
2-Keto-L-gulonic acid	526-98-7
Phthalonic acid	528-46-1
2-Keto-4-methylthiobutyric acid	583-92-6
alpha-Ketobutyric acid	600-18-0
Phenylglyoxylic acid	611-73-4
Phenylglyoxylic acid	611-73-4
alpha-Ketoisovalerate	759-05-7
Hydroxydiiodophenylpyruvic acid	780-00-7
alpha-Ketoisocaproic acid	816-66-0
3-Deoxy-2-octulosonic acid	1069-03-0
Vanilpyruvic acid	1081-71-6
2-Hydroxy-4-oxopentanedioic acid	1187-99-1
alpha-Keto-beta-methylvaleric acid	1460-34-0
alpha-Oxofuran-2-acetic acid	1467-70-5
2-Ketopentanoic acid	1821-02-9
beta-Hydroxy-alpha-ketobutyric acid	1944-42-9
Vanilglycolic acid	2021-40-1
alpha-Ketocaproic acid	2492-75-3
3-Deoxy-D-arabino-2-heptulosonic acid 7-phosphate	2627-73-8
alpha-Ketoadipic acid	3184-35-8
alpha-Keto-delta-guanidinovaleric acid	3715-10-4
alpha-Oxothiophen-2-acetic acid	4075-59-6
3,4-Dihydroxyphenylpyruvic acid	4228-66-4
2-Keto-4-mercaptobutyric acid	4273-28-3
alpha-Oxocyclohexaneacetic acid	4354-49-8
2-Nitrophenylpyruvic acid	5461-32-5
Ketohypoglycin	5746-24-7
3,4-Didehydro-2-ketoglutaric acid	6004-32-6
4-chloro-alpha-oxobenzeneacetic acid	7099-88-9
4-Methylbenzoylformic acid	7163-50-0
3-Deoxy-2-ketoarabinonic acid	7636-04-6
Amidinophenylpyruvic acid	10290-63-8
4-Hydroxyphenylglyoxylic acid	15573-67-8
Provitamin C	16533-48-5
4-Aminophenylpyruvic acid	16921-36-1
3-Deoxy-D-erythro-2-hexulosonic acid	17510-99-5
4-(((Aminoiminomethyl)amino)oxy)-2-oxobutanoic acid	17774-31-
5-Amino-2,5-dioxopentanoic acid	18465-19-5
2-Ketogluconate	20248-27-5
2-Keto-4-pentenoic acid	20406-62-6
3-Deoxyglycero-galactononulosonic acid	22594-61-2
Ketomycin	23364-22-9
N-Acetylisatic acid	32375-61-4
N-4-Chlorobenzoylisatinic acid	54778-24-4
N-Benzoylisatinic acid	54778-23-3
2-Keto-3-butynoic acid	56842-75-2
2-Keto-3-deoxyoctonic acid 5-phosphate	57717-01-8
2-Oxo-4-hydroxyarginine	64186-82-9
2-Keto-3-bromobutanoic acid	71183-36-3
alpha-Ketokainic acid	75232-58-5
3-Bromo-2-ketopentanedioic acid	76444-16-1
alpha-Ketosuberic acid	96406-05-2
2-Keto-3-deoxy-1,7-dicarboxyheptonic acid	99778-26-4
4-(chloromethyl)-alpha-oxobenzeneacetic acid	114996-73-5
5-Hydroxy-6-(2-keto-3-thiopropionyl)-7,9,11,14-eicosatetraenoic acid	117675-20-4
Clavicoronic acid	139748-98-4

Pyruvic acid is a liquid with acetic-acid smell; melting point 11 - 12 C; solube in water. It occurs naturally as an intermediate product in carbohydrate and protein metabolism in the body. The six-carbon glucose molecule is broken down to two molecules of pyruvic acid in aerobic condition as the main input for Krebs cycle, whereas to two molecules of lactic acid (alpha hydroxy acid) in anaerobic condition. Krebs cycle (also called citric acid cycle; tricarboxylic acid cycle) is a sequent process of enzymatic reaction which a two-carbon acetyl unit is oxidized to carbon dioxide and water to provide energy in the form of high-energy phosphate bonds. In commercial, pyruvic acid is used to produce its salts and esters (pyruvates) for the use as dietary supplements of the effective weight loss enhancers . Pyruvic acid is used for the synthesis of amino acids (alanine, tyrosine, phenylalanine, and tryptophan) and used in biochemical research. Its derivatives are used in making food additives and flavoring agents.

EXAMPLES OF NATURALLY OCCURRING CARBOXYLIC ACIDS
(excluding fatty acids)

Pyruvic acid	Lactic Acid	Cholic acid	Nicotinic acid

metabolic intermediate	metabolic intermediate	from bile	vitamin B

Citric acid	Malic Acid	Biotin	Abietic acid

in plants	in fruits	cell growth factor	pine rosin