| (R)-2-METHYLPIPERAZINE | ||
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PRODUCT IDENTIFICATION |
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| CAS NO. | 75336-86-6 |
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| EINECS NO. | 203-644-2 | |
| FORMULA | C5H12N2 | |
| MOL WT. | 100.10 | |
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H.S. CODE |
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| TOXICITY |
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| SYNONYMS | (R)-(-)-2-Methylpiperazine; | |
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DERIVATION |
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CLASSIFICATION |
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PHYSICAL AND CHEMICAL PROPERTIES |
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| PHYSICAL STATE |
white to off-white crystals |
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| MELTING POINT | 91 - 93 C | |
| BOILING POINT | 155 - 156 C | |
| SPECIFIC GRAVITY | ||
| SOLUBILITY IN WATER | Soluble | |
| pH | ||
| VAPOR DENSITY |
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AUTOIGNITION |
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NFPA RATINGS |
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REFRACTIVE INDEX |
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| FLASH POINT |
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| STABILITY |
Stable under ordinary conditions. Moisture, light sensitive. |
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GENERAL DESCRIPTION |
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| Chiral piperazine derivatives, containing 6--membered diazaheterocycle enantiomeric intermediates, have become increasingly important in asymmetric synthesis in biological and pharamceutical activities. (R)-2-Methylpiperazine is important for quinoline antibiotics. | ||
| SALES SPECIFICATION | ||
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APPEARANCE |
white to off-white crystals |
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CHEMICAL PURITY |
98.0% min | |
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OPTICAL PUIRTY |
98.0% min e.e. | |
| TRANSPORTATION | ||
| PACKING |
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| HAZARD CLASS | 4.1 (Packing Group: III) | |
| UN NO. | 2925 | |
| OTHER INFORMATION | ||
| Hazard Symbols: XI, F, Risk Phrases: 11-36/37/38,
Safety Phrases: 16-26-36/37/39 Optical Rotation: -16.5 ±1° (C=5 in MeOH) |
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| GENERAL DESCRIPTION OF PIPERAZINE | ||
| Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane. Piperazine is a main moiety in psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes. Benzylpiperazine is bannaed in many countries. Benzylpiperazine has been used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an important role in biological research and drug manufacturing industry including the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic, antiemetic and antimigraine agents. The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants. | ||
