(R)-4-PHENYL-2-OXAZOLIDINONE

PRODUCT IDENTIFICATION
CAS NO. 90319-52-1

(R)-4-PHENYL-2-OXAZOLIDINONE
EINECS NO.  
FORMULA C9H9NO2
MOL WT. 163.18

H.S. CODE

  

TOXICITY

 

DERIVATION

 
SYNONYMS

R-4-Phenyl-oxazolidin-2-one; (R)-(-)-4-Phenyl-2-oxazolidinone;

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

white crystalline powder
MELTING POINT 129 - 134 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

  

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT

 
STABILITY

Stable under ordinary conditions. Hygroscopic.

GENERAL DESCRIPTION

Oxazolidinones, containing not only nitrogen but also oxygen atom in lactam ring, are used in developing novel drug especially antibiotics of low toxicity for the host but effective against penicillin-resistant pathogens. Chiral oxazolidinones are used in the enantioselective synthesis of beta-lactams and alpha-amino acids. End products can include asysmmetric single isomeric drugs of antitumor, anesthetic, antipasmodic, hepatotoxic, antiinflammatory or anti-HIV activity products. Chiral oxazolidinones have wide and effective chiral applications as chiral auxiliaries, building blocks and ligands.
SALES SPECIFICATION

APPEARANCE

white crystalline powder

CHEMICAL PURITY

 98.5% min

OPTICAL PUIRTY

 99.0% min e.e.

LOSS ON DRYING

 0.5% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: , Risk Phrases: , Safety Phrases: 24-26
Optical Rotation: -47.5° ~ -48.5° (C=2 in Chloroform)

GENERAL DESCRIPTION OF LACTONE

Lactone, Lactam, Lactim

Lactone is an internal cyclic monoester (anhydride) derived from the hydroxyl and carboxyl radicals of gamma or delta hydroxy acids by the removal of a H2O between a carboxyl and a hydroxyl group in the same molecule; gamma-hydroxybutyric acid forms gamma-butyrolactone and delta-hydroxydecanoic acid forms delta-decalactone spontaneously. In result, prefixes describe the ring size: beta- is for 4-membered ring), gamma- , 5-membered, and delta-, 6-membered ring. Lactam (a cyclic amide) is the nitrogen analog of lactone. Gamma-aminobutyric acid forms gamma-butyrolactam (also called 2-pyrrolidinone). Lactim is the tautomeric enol form of lactam. Lactam structure, a heteroatomic cyclic amide compound, is an important part in antibiotics such as penicillin. These structures, cyclic esters and analogues, are active nucleuses in pharmacological activity and flavorings. Their good solvency properties also useful in industrial application. Lactams have big demand in artificial fibre industry. They are polymerizable and used as nylon precursors.