D-LEUCINOL

PRODUCT IDENTIFICATION
CAS NO. 53448-09-2

D-LEUCINOL
EINECS NO.  
FORMULA C6H15NO
MOL WT. 117.19

H.S. CODE

  

TOXICITY

 
SYNONYMS (R)-(-)-Leucinol; R-(-)-2-Amino-4-methyl-1-pentanol;
D-(-)-Leucinol; (R)-2-amino-4-methyl-1-Pentanol; (R)-2-amino-4-metilpentan-1-ol; (R)-2-amino-4-méthylpentane-1-ol;

DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE

clear to pale yellow liquid
MELTING POINT  
BOILING POINT 198 - 200 C
SPECIFIC GRAVITY 0.91 - 0.92
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

  

NFPA RATINGS

  

REFRACTIVE INDEX

 1.4511
FLASH POINT

90 C
STABILITY

Stable under ordinary conditions. Hygroscopic.

GENERAL DESCRIPTION

Chiral amino alcohols and their N-protected derivatives (Cbz, t-Boc, and Fmoc) are versatile building blocks, auxiliaries, ligand or resolving agent in asymmetric synthesis for biological research and pharmaceutical applications such as antitumor, anesthetic, antipasmodic, hepatotoxic, antiinflammatory or anti-HIV activities. They are used in the synthesis of beta-blockers, HIV protease and ACE inhibitors, chiral auxiliaries and catalytic enantioselective ligands. Their derivatives include the forms of;
  • C-terminal peptibiols
  • Amphiphylic antibacterial peptides
  • Oligocarbamates
  • Analogs of peptides
  • Aziridines, Halogen aminoalkyls
  • Enantiomerical alpha-alkyl mono and diamines
  • Enantiomerical beta-substituted amines
  • Enantiomerical beta-amino acids beta-amino sulfoxides, beta-amino sulfides and beta-amino thiols.
  • The precursors of diverse compounds such as statines, sphingolipides and peptide isosteres.

Examples of leucinol molecules

Product

CAS RN
Leucinocaine mesylate 135-44-4
Isoleucinol 4379-13-9

L-Leucinol

7533-40-6

D-Leucinol

53448-09-2
Vinleucinol 81571-28-0

Boc-L-leucinol

82010-31-9
Neurotensin-related hexapeptide 85213-84-9

D-tert-Leucinol

112245-09-7

L-tert-Leucinol

112245-13-3
N-Cinnamyl-D,L-leucinol 127750-61-2
N-Cinnamoyl-D-leucinol 127852-95-3
Trichodecenin II 140939-04-4
Trichodecenin I 141024-74-0

Boc-D-Leucinol

142121-48-0

L-N-Boc-tert-leucinol

153645-26-2

N-Z-D-Leucinol

166735-51-9
SALES SPECIFICATION

APPEARANCE

clear to pale yellow liquid

IDENTIFICATION

pass IR

CHEMICAL PURITY

 97.5% min

OPTICAL PURITY

 97.5% min

WATER

 1.0% max
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36
Optical Rotation: -3° ~ -5° (C=9 in EtOH))