METHIONINE, an essential amino acid (sulfur-containing)
that is not synthesized by the body and must be obtained from food. It
contributes to supply mineral sulfur improving the tone and pliability of the
skin, conditioning the hair and strengthens nails and protecting the cells from
airborne pollutants. It contributes to the other compounds including
S-adenosyl-methionine (SAM), which participate in liabile methyl groups and
sulfur to over 100 biochemical reactions for normal brain function, and
L-Cysteine, which is a component of Glutathione, an important antioxidant
molecule in the body. Methionine is also a transporter of the antioxidant
mineral Selenium. METHIONINE occurs as two optical isomers, a dextro and
a levo form.
Chiral amino alcohol possessing both amine and alcohol is a structural motif for
the compounds which have important biological and pharmacological functions
within the body as inhibitor of aspartyl proteases, aldose reductase, b-amyloid
peptide formation, and dopamine D4 antagonists. The chiral amino alcohol also
exhibits anti-inflammatory, anesthetic, antipasmodic, hepatotoxic,
anti-diabetic, anti-obesity,and anti-depressant activities. Chiral amino
alcohols and their N-protected derivatives (Cbz, t-Boc, and Fmoc) are versatile
building blocks, auxiliaries, ligand or resolving agent in asymmetric synthesis
for biological and pharmaceutical researches. applications are present in the
field of antitumor, anesthetic, antipasmodic, hepatotoxic, antiinflammatory or
anti-HIV activities. Their derivatives include the forms of;
- C-terminal peptibiols
- Amphiphylic antibacterial
peptides
- Oligocarbamates
- Analogs of peptides
- Aziridines, Halogen
aminoalkyls
- Enantiomerical alpha-alkyl mono and diamines
- Enantiomerical
beta-substituted amines
- Enantiomerical beta-amino acids beta-amino
sulfoxides, beta-amino sulfides and
- beta-amino thiols.
- The precursors of
diverse compounds such as statines, sphingolipides and peptide isosteres.
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