5-FLUOROOROTIC ACID

Synonyms. 5-Fluoroorotic acid; 5-Fluorouracil-4-carboxylic acid; 5-Fluoruracil-4-carbonsäure (Dutch); ácido 5-fluorouracilo-4-carboxílico (Spanish); Acide 5-fluorouracile-4-carboxylique (French); 5-FOA; 1,2,3,6-Tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid; 5-Fluoroorotate; 5-Fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid;

5-FLUOROOROTIC ACID

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

703-95-7

EINECS RN

211-876-0

FORMULA

 C5H3FN2O4

MOLE WEIGHT

 174.09

H.S CODE

 2933.59.9500

SMILES

 c1(c([nH]c(=O)[nH]c1=O)C(=O)O)F

CLASSIFICATION

Fluorogenic

EXTRA NOTES

A pyrimidinemonocarboxylic that is orotic acid which is substituted by fluorine at position 5. It is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate dicarboxylase. A yeast with and active URA3 gene converts 5-fluoroorotic acid to fluorodeoxyuridine, which is toxic to cells.[ChEBI]

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to pale yellow powder

MELTING POINT

275 ~ 278 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Sparingly soluble

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

 -0.08

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - 5-Fluoroorotic acid

Wikipedia Linking - Orotic acid

Google Scholar Search - 5-Fluoroorotic acid

U.S. National Library of Medicine - 5-Fluoroorotic acid

PubChem Compound Summary - 5-Fluoroorotic acid

ChEBI (http://www.ebi.ac.uk/chebi/) -  5-Fluoroorotic acid

NCBI (http://www.ncbi.nlm.nih.gov/) -  5-Fluoroorotic acid

Local:
APPLICATION:5-Fluoroorotic Acid is a selective agent in yeast genetics such as identification of mutant yeast strains, yeast 2-hybrid system and gene replacement. It isolates orotidine-5'-monophosphate decarboxylase gene (pyrF).

GENERAL DESCRIPTION OF OROTIC ACID: Orotic acid: Uracil-6-carboxylic acid, is an intermediate in the metabolism of pyrimidine nucleotides. Naturally occurring derivatives are components of nucleic acids: cytosine, thymidine, and uracil).
Orotidine: a nucleoside, orotic acid N1 is linked to the C1 of ribose.
Orotidine 5'-phosphate: an intermediate in pyrimidine nucleotide biosynthesis. They are used as a cosmetic ingredient, in medicine, as a feed supplement and in biochemical research.

 

SALES SPECIFICATION

APPEARANCE

white to pale yellow powder

ASSAY

99.0% min

MELTING POINT

270 ~ 278 C

WATER

10.5% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Dermal). Skin irritation. Serious eye damage. Acute aquatic toxicity. Hazard statements: Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Very toxic to aquatic life.

SIGNAL WORD Warning

PICTOGRAMS

PICTOGRAM_GHS07_exclamation.jpg

HAZARD STATEMENTS

H302-H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338-P273

EC DIRECTIVES

 

HAZARD CODES

CODE_Xn_Xi_harmful_Irritant.gif

RISK PHRASES

22-36/37/38

SAFETY PHRASES

26-36

 

PACKING

Preserved in light-resistant and well-closed bottles

 

PRICE INFORMATION