CAS
NO. |
18942-49-9 |
|
EINECS
NO. |
|
FORMULA |
C14H19NO4 |
MOL
WT. |
265.31 |
H.S.
CODE
|
|
TOXICITY
|
|
SYNONYMS |
Boc-D-Phe-OH;
N-alpha-t-BOC-D-phenylalanine;
|
N-(tert-Butoxycarbonyl)-D-phenylalanine;
N-(terc-butoxicarbonil)-D-fenilalanina; N-(tert-butoxycarbonyl)-D-phénylalanine;
|
DERIVATION |
|
CLASSIFICATION
|
AMINO ACIDS
/
|
PHYSICAL AND CHEMICAL PROPERTIES
|
PHYSICAL
STATE |
White to off-white
crystalline
powder |
MELTING POINT |
86 - 88 C |
BOILING
POINT |
|
SPECIFIC GRAVITY |
|
SOLUBILITY
IN WATER |
|
pH |
|
VAPOR DENSITY |
|
AUTOIGNITION
|
|
NFPA
RATINGS
|
Health:
1; Flammability: 0; Reactivity:
0 |
REFRACTIVE
INDEX
|
|
FLASH
POINT |
|
STABILITY |
Stable
under ordinary conditions. Moisture and light sensitive |
GENERAL
DESCRIPTION & APPLICATIONS
|
Phenylalanine is an essential amino acid obtained in the levo form by hydrolysis
of proteins (as lactalbumin). Branched amino-acids (Valine, Isoleucine and Leucine ) with tryptophan
and phenylalanine (aromatic side chain amino acids) contribute to the structure
of protein by the tendency of its side chain composed only of carbon and
hydrogen to participate in hydrophobic interactions which determines the
tertiary structure of the peptide chain. In addition to its role in protein synthesis, it
is the metabolic precursor of the non-essential amino acid tyrosine which makes
hormones, such as norepinephrine and epinephrine in the normal body.
The prefix nor- describes
normal structure which has no branched chain of carbon atoms. But in case of
norepinephrine, it has one less methylene group than its homologue, epinephrine.
Phenylalanine is also converted to
phenylethylamine occuring naturally in the brain
to elevate mood. It is used to treat depression, inflammation, chronic pain,
Parkinson's disease. Phenylalanine is a key intermediate to make aspartame.
N-alpha-t-BOC-D-phenylalanine
is
used in biological research of peptidomimetics. It is used to prepare unnatural
and unusual amino acids and amino acid analogs as well as to modify peptides. |
SALES
SPECIFICATION |
APPEARANCE
|
White to off-white
crystalline
powder |
ASSAY
|
99.0%
min |
OPTICAL ROTATION
[a]20 |
-24°
~
-26° (C=1
in EtOH) |
SOLUTION CLARITY |
clear
|
Fe
|
10ppm
max
|
HEAVY METALS |
10ppm
max
|
As
|
2ppm
max
|
LOSS ON
DRYING |
0.5%
max
|
TRANSPORTATION |
PACKING |
|
HAZARD CLASS |
Not
regulated |
UN
NO. |
|
OTHER
INFORMATION |
Hazard Symbols: XI, Risk Phrases: 36/37/38,
Safety Phrases: 26-36 |
PRICES
|
|