Wikipedia
Linking - Dipeptide
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Compound
Summary
- Fmoc-Gly-Gly-OH
http://www.ncbi.nlm.nih.gov/
- Fmoc-Gly-Gly-OH
http://www.peptideguide.com/ Dipeptide (DP) is actually one molecule, which consists of 2 amino acids that
are joined by a single peptide bond. Since it consists of 2 different amino
acids, it can have different sequences, like Ala-Gly or Gly-Ala. Such dipeptides
would have different chemical and biological properties. The matter is that if
written left to right in Gly-Ala, the glycine has the 'free' amine terminal end,
while alanine has the 'free' carboxyl acid terminal end. Dipeptide can be produced in different ways, which are generally divided into
3 methods: chemical synthesis, chemoenzymatic synthesis, and enzymatic
synthesis. Meanwhile, the function of di-peptides can be viewed from two points: as a
derivative of amino acid and as the dipeptide itself. The first one is quite
easy to understand, since although DPs and the constitutive amino acids feature
different physicochemical properties, they should still share the same
physiological effects, because dipeptides are degraded into the individual amino
acids in organisms. For instance, L-Glutamine is heat labile, but L-alanyl-L-glutamine is more
tolerant to heat. Another good example is solubility: while Tyr is practically
insoluble, you can dissolve Ala-Tyr up to 14 g/L. The most interesting fact is
that a number of dipeptides are more soluble than each of the constitutive amino
acids. For example, the solubilities of Ala and Gln are 89 and 36 g/L
accordingly, but that of Ala-Gln is 586 g/L! Considering these properties and
the fact that Ala-Gln and Gly-Tyr are quickly degraded into the individual amino
acids when taken into the body, these dipeptides are used as components of
patient infusions.
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