N-alpha-Fmoc-L-LEUCINE

N-alpha-Fmoc-L-LEUCINE

PRODUCT IDENTIFICATION

CAS NO.

35661-60-0

EINECS NO.

252-662-7

FORMULA C₂₁H₂₃NO₄

MOL WT. 353.42

H.S. CODE

2922.49

TOXICITY

SYNONYMS FMOC-leucine; FMOC-L-Leucine;

N-(9-Fluorenylmethoxycarbonyl)-L-leucine; Fmoc-Leu-OH;

DERIVATION

CLASSIFICATION

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE White crystalline powder

MELTING POINT 152 - 154 C

BOILING POINT

SPECIFIC GRAVITY

SOLUBILITY IN WATER

VAPOR DENSITY

AUTOIGNITION

NFPA RATINGS

Health: 1; Flammability: 0;Reactivity: 0

REFRACTIVE INDEX

FLASH POINT

STABILITY

Stable under ordinary conditions. Moisture and light sensitive

GENERAL DESCRIPTION & APPLICATIONS

Valine, Isoleucine and Leucine are all branched-chain amino acids which can be burned for fuel in the cells to promotes muscle recovery when in balance with each other most effective. Only the L-stereoisomers appear in mammalian protein. They play a role in wound healing and the growth of new tissue. These branched amino-acids are needed to increase the bio-availability of complex carbohydrate intake and are absorbed by the muscle cells for anabolic muscle building activity. Branched amino-acids (Valine, Isoleucine and Leucine ) with tryptophan and phenylalanine (aromatic side chain amino acids) contribute to the structure of protein by the tendency of its side chain composed only of carbon and hydrogen to participate in hydrophobic interactions which determines the tertiary structure of the peptide chain. Isoleucine, chemically 2-amino-3-methylvaleric acid, is a monocarboxylic amino acid occurring in most dietary proteins. It is necessary for optimal growth in infants and for nitrogen equilibrium in human adults. Leucine, chemically 2-amino-4-methylvaleric acid, is the isomer of isoleucine. Their methyl branch positions are difference, which show different properties of them. Norleucine, chemically 2-aminohexanoic acid, is the unbranched isomer. The prefix nor- describes normal structure which has no branched chain of carbon atoms. (In case of norepinephrine, it has one less methylene group than its homologue, epinephrine). Norleucine is a nonessential amino acid extracted from the leucine fraction of the decomposition of the proteins of nervous tissue. Commercial norleucine is synthesized for peptidomimetics to prepare unnatural and unusual amino acids and amino acid analogs as well as to modify peptides. N-alpha-FMOC-L-leucine is an unnatural amino acid for peptidomimetics and biological research.

SALES SPECIFICATION

APPEARANCE

White crystalline powder

ASSAY

98.5% min

OPTICAL ROTATION [a]²⁰ -23.5° ~ -15.5° (C=1 in DMF)

SOLUTION CLARITY

clear

10ppm max

HEAVY METALS

10ppm max

2ppm max

LOSS ON DRYING

0.5% max

TRANSPORTATION

PACKING

HAZARD CLASS Not regulated

UN NO.

OTHER INFORMATION

Hazard Symbols: n/a, Risk Phrases: n/a, Safety Phrases: 24/25-28A-37-45

GENERAL DESCRIPTION OF AMINO ACID

Amino Acid	Abbreviation		Formula (Mol WT)	pK₁	pK₂	pK_R	pI	Hydropathy Index
Amino Acid	3-Letters	1-Letter	Formula (Mol WT)	-COOH	-NH₃⁺	R group	pI	Hydropathy Index
Alanine	Ala	A	C₃H₇NO₂(89.09)	2.34	9.69	-	6.00	1.8
Arginine	Arg	R	C₆H₁₄N₄O₂(174.20)	2.17	9.04	12.48	10.76	-4.5
Asparagine	Asn	N	C₄H₈N₂O₃(132.12)	2.02	8.80	-	5.41	-3.5
Aspartic Acid	Asp	D	C₄H₇NO₄(133.10)	1.88	9.60	3.65	2.77	-3.5
Cysteine	Cys	C	C₃H₇NO₂S(240.30)	1.96	10.128	8.18	5.07	2.5
Glutamic Acid	Glu	E	C₅H₉NO₄(147.13)	2.19	9.67	4.25	3.22	-3.5
Glutamine	Gln	Q	C₅H₁₀N₂O₃(146.15)	2.17	9.13	-	5.65	-3.5
Glycine	Gly	G	C₂H₅O₂(75.07)	2.34	9.60	-	5.97	-0.4
Histidine	His	H	C₆H₉N₃O₂(155.16)	1.82	9.17	6.00	7.59	-3.2
Isoleucine	Ile	I	C₆H₁₃NO₂(131.18)	2.36	9.60	-	6.02	4.5
Leucine	Leu	L	C₆H₁₃NO₂(131.18)	2.36	9.60	-	5.98	3.8
Lysine	Lys	K	C₆H₁₄N₂O₂(146.19)	2.18	8.95	10.53	9.74	-3.9
Methionine	Met	M	C₅H₁₁NO₂S(149.21)	2.28	9.21	-	5.74	1.9
Phenylalanine	Phe	F	C₉H₁₁NO₂(165.19)	1.83	9.13	-	5.48	2.8
Proline	Pro	P	C₅H₉NO₂(115.13)	1.99	10.60	-	6.30	1.6
Serine	Ser	S	C₃H₇NO₃(105.19)	2.21	9.15	-	5.58	-0.8
Threonine	Thr	T	C₄H₉NO₃(119.12)	2.09	9.10	-	5.60	-0.7
Tryptophan	Trp	W	C₁₁H₁₀N₂O₂(204.23)	2.83	9.39	-	5.89	-0.9
Tyrosine	Tyr	Y	C₉H₁₁NO₃(181.19)	2.20	9.11	10.07	5.66	-1.3
Valine	Val	V	C₅H₁₁NO₂(117.15)	2.32	9.62	-	5.96	4.2