APREMILAST

Synonyms. Apremilast; (+)-N-(2-((1S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl)-1,3-dioxo- 2,3-dihydro-1H-isoindol-4-yl)acetamide; Apremilastum; Otezlareg;

APREMILAST

 

PRODUCT IDENTIFICATION

CAS RN

608141-41-9

EINECS RN

 

FORMULA

C22H24N2O7S

MOLE WEIGHT

460.50

H.S CODE

  

SMILES

 O=S(=O)(C)C[C@H](c1ccc(OC)c(OCC)c1)N3C(=O)c2cccc(c2C3=O)NC (=O)C

CLASSIFICATION

Analgesic, Anti-Inflammatory agent, Phosphodiesterase Inhibitor

EXTRA NOTES

Treatment of chronic inflammatory conditions including psoriasis, arthritis, asthma and cutaneous lupus erythematosus (CLE)
A member of the class of isoindoles that is isoindole-1,3-dione substituted at position 4 by an acetamido group and at position 1 by a 1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl group. Used for treatment of psoriatic arthritis. ebi.ac.uk

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Insoluble

SOLVENT SOLUBILITY

Soluble in DMSO

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Apremilast

Wikipedia Linking - Apremilast

Google Scholar Search - Apremilast

U.S. National Library of Medicine - Apremilast

PubChem Compound Summary - Apremilast

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Apremilast

ChEBI (http://www.ebi.ac.uk/chebi/) -  Apremilast

NCBI (http://www.ncbi.nlm.nih.gov/) -  Apremilast

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

CHEMICAL PURITY

99.0% min

OPTICAL PURITY

99.0% min

LOSS ON DRYING

0.5% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Harmful if swallowed. Irritating to eyes, respiratory system and skin. Inhalation:May be harmful if inhaled. Causes respiratory tract irritation. Skin:May be harmful if absorbed through skin. Causes skin irritation. Eyes: Causes eye irritation. Ingestion: Harmful if swallowed.

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

R22: Harmful if swallowed.
R36/37/38: Irritating to eyes, respiratory system and skin.

SAFETY PHRASES

S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37: Wear suitable protective clothing and gloves.

 

PACKING

Preserve in light-resistant and well-closed containers

 

PRICE INFORMATION