ARISTOLOCHIC ACID I

Synonyms. Aristolochic acid; Tardolyt; Aristolochine; Aristolochic acid I; 3,4-Methylenedioxy- 8-methoxy-10-nitro-1-phenanthrenecarboxylic acid; 8-Methoxy-3,4-methylendioxxy-10-nitro-1- phenanthrencarbonsaeure; 8-Methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid; Aristolochiazaeure; 8-Methoxy-6-nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid; Aristinic acid; Aristolochia yellow; Aristolochic acid A;

ARISTOLOCHIC ACID I

 

PRODUCT IDENTIFICATION

CAS RN

313-67-7

EINECS RN

206-238-3

FORMULA

C17H11NO7

MOLE WEIGHT

341.27

H.S CODE

 2932.99.6100

SMILES

 [O-][N+](=O)c1cc4c(c2c1c(C(=O)O)cc3OCOc23)cccc4OC

CLASSIFICATION

Anti-Infective, Alkaloid

EXTRA NOTES

Phospholipase A inhibitor.
Other RN: 12770-90-0, 61117-05-3.
Aristolochic acid (mixture of I and II, Approx. 1:1)
CAS: 313-67-7
Chemical Name: Aristolochic acid I
EINECS: 206-238-3
CAS: 475-80-9
Chemical Name: Aristolochic acid II
EINECS: 207-499-6.
A monocarboxylic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. ebi.ac.uk

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white powder

MELTING POINT

269 ~ 270 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Slightly soluble

SOLVENT SOLUBILITY

Soluble in alcohol, chloroform, ether, acetone, acetic acid, aniline, alkalies. Practically insoluble in benzene, carbon disulfide

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Aristolochic acid

Wikipedia Linking - Aristolochic acid

Google Scholar Search - Aristolochic acid

U.S. National Library of Medicine - Aristolochic acid

PubChem Compound Summary - Aristolochic acid

Drug Bank -  Aristolochic acid

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Aristolochic acid

ChEBI (http://www.ebi.ac.uk/chebi/) -  Aristolochic acid

NCBI (http://www.ncbi.nlm.nih.gov/) -  Aristolochic acid

 

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

98% min

MELTING POINT

269 ~ 270 C

LOSS ON DRYING

0.5% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

1544

HAZARD CLASS

6.1

PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

Warning! Cancer suspect agent. May cause kidney damage. Harmful if swallowed, inhaled, or absorbed through the skin. Causes eye, skin, and respiratory tract irritation. Target Organs: Kidneys, respiratory system, eyes, skin. Potential Health Effects Eye: Causes eye irritation. Skin: Causes skin irritation. Harmful if absorbed through the skin. Ingestion: Harmful if swallowed. May cause irritation of the digestive tract. May cause kidney damage. Inhalation: Harmful if inhaled. Causes respiratory tract irritation. Chronic: Prolonged or repeated skin contact may cause dermatitis. May cause kidney damage.

SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H350: May cause cancer
H319: Causes serious eye irritation
H331:Toxic if inhaled
H301:Toxic if swallowed
H315:Causes skin irritation
H335:May cause respiratory irritation
H341:Suspected of causing genetic defects
H311:Toxic in contact with skin

PRECAUTIONARY STATEMENTS

P301 + P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician
P280:Wear protective gloves/protective clothing/eye protection/face protection
P312:Call a POISON CENTER or doctor/physician if you feel unwell
P302 + P350:IF ON SKIN: Gently wash with plenty of soap and water
P281:Use personal protective equipment as required
P201:Obtain special instructions before use
P308 + P313:IF exposed or concerned: Get medical advice/attention
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P261:Avoid breathing dust/fume/gas/mist/vapors/spray
P302+ P352:IF ON SKIN: Wash with plenty of soap and water
P280:Wear protective gloves/protective clothing/eye protection/face protection
P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

R 45 May cause cancer.
R 23/24/25 Toxic by inhalation, in contact with skin and if swallowed.
R 36/37/38 Irritating to eyes, respiratory system and skin.
R 68 Possible risk of irreversible effects.

SAFETY PHRASES

S 53 Avoid exposure - obtain special instructions before use.
S 26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S 36/37/39 Wear suitable protective clothing, gloves and eye/face protection.
S 45 In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

 

PACKING

Preserve in light-resistant and well-closed containers

 

PRICE INFORMATION