BENZAMIDINE

Synonyms. Benzamidine; Phenylamidine; Benzenecarboximidamide; Phenylamidine; Benzenecarboxamidine;

BENZAMIDINE 

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

618-39-3 (free base), 1670-14-0 (hydrochloride)

EINECS RN

210-546-3 (free base), 216-795-4 (hydrochloride)

FORMULA

 C6H5C(=NH)NH2

MOLE WEIGHT

120.15

H.S CODE

 2925.29.6000

SMILES

 c1cc(ccc1)C(N)=N

CLASSIFICATION

Enzyme Inhibitor, Amidine

EXTRA NOTES

 

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Benzamidine

Wikipedia Linking - Benzamidine

Google Scholar Search - Benzamidine

U.S. National Library of Medicine - Benzamidine

PubChem Compound Summary - Benzamidine

Drug Bank -  Benzamidine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Benzamidine

ChEBI (http://www.ebi.ac.uk/chebi/) -  Benzamidine

NCBI (http://www.ncbi.nlm.nih.gov/) -  Benzamidine

EPA - Substance Registry Services - Benzamidine hydrochloride

http://www.sigmaaldrich.com/
Biochem/physiol Actions: Benzamidine HCl is a reversible inhibitor of trypsin, trypsin-like enzymes, and serine proteases. A concentration of approximately 1 mM is used for general protease inhibition. To inhibit proteases from yeast, a range of 0.5 to 4.0 mM is used and it is for the most part interchangeable with pepstatin A. In addition to being a strong competitive inhibitor of trypsin, benzamidine HCl has been also shown to be a strong competitive inhibitor of thrombin and plasmin. It was also found to be as effective as aprotinin in the prevention of glucagon degradation in human plasma.

 

SALES SPECIFICATION (hydrochloride monohydrate)

APPEARANCE

white to off-white crystalline powder

ASSAY

98% min

MELTING POINT

84 ~ 86 C

WATER

15% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Eye irritation. Hazard statements: Harmful if swallowed. Causes serious eye irritation.

SIGNAL WORD Warning

PICTOGRAMS

PICTOGRAM_GHS07_exclamation.jpg

HAZARD STATEMENTS

H302-H319

P STATEMENTS

P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

CODE_Xn_Xi_harmful_Irritant.gif

RISK PHRASES

22-36

SAFETY PHRASES

26-36

 

PACKING

Preserved in light-resistant and well-closed bottles

 

PRICE INFORMATION