CALCIMYCIN

Synonyms. Calcimycin; Calcium Ionophore A23187; 5-(Methylamino)-2-(((2R,3R,6S,8S,9R,11R) -3,9,11-trimethyl-8- ((1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)ethyl)- 1,7-dioxaspiro(5.5)undec-2-yl)methyl) -4-benzoxazolecarboxylic acid; Calcium Ionophore III;

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PRODUCT IDENTIFICATION

CAS RN

52665-69-7

EINECS RN

258-084-1

FORMULA

C29H37N3O6

MOLE WEIGHT

523.62

H.S CODE

 2934.99.3900

SMILES

 O=C(O)c1c(NC)ccc2oc(nc12)C[C@H]5O[C@]3(O[C@@H]([C@H](C) C[C@H]3C )[C@@H] (C(=O)c4cccn4)C)CC[C@H]5C

CLASSIFICATION

Antibacterial, Calcium Ionophore, Ionophore

EXTRA NOTES

Other RN: 37259-87-3, 37263-57-3, 51257-80-8, 51310-65-7, 53095-21-9
An ionophorous, polyether antibiotic from Streptomyces chartreusensis. It binds and transports CALCIUM and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems. 

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white powder

MELTING POINT

181 ~ 183 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

Slightly soluble

SOLVENT SOLUBILITY

Soluble in DMSO, ethylacetate, methanol, ethanol

VAPOR DENSITY

 

log P(octanol-water)

 7.31

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Calcimycin

Wikipedia Linking - Calcimycin

Google Scholar Search - Calcimycin

U.S. National Library of Medicine - Calcimycin

PubChem Compound Summary - Calcimycin

Drug Bank -  Calcimycin

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Calcimycin

ChEBI (http://www.ebi.ac.uk/chebi/) -  Calcimycin

NCBI (http://www.ncbi.nlm.nih.gov/) -  Calcimycin

Material Safety Data Sheet - Calcimycin

 

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

99% min

MELTING POINT

180 ~ 190 C

OPTICAL ACTIVITY

-55° ~ -57° (c=1 in chloroform)

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Skin irritation. Eye irritation. Specific target organ toxicity - single exposure.

SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H312: Harmful in contact with skin
H332: Harmful if inhaled
H335: May cause respiratory irritation
H315: Causes skin irritation
H302: Harmful if swallowed
H319: Causes serious eye irritation

PRECAUTIONARY STATEMENTS

P302 + P352: IF ON SKIN: Wash with plenty of soap and water
P280: Wear protective gloves/protective clothing/eye protection/face protection P261: Avoid breathing dust/fume/gas/mist/vapors/spray
P301+ P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell
P304 + P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
P280: Wear protective gloves/protective clothing/eye protection/face protection P305 + P351 + P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
36/37/38: Irritating to eyes, respiratory system and skin.

SAFETY PHRASES

26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
36/37/39: Wear suitable protective clothing, gloves and eye/face protection.

 

PACKING

Preserve in light-resistant and well-closed containers

 

PRICE INFORMATION