CHELIDONINE

Synonyms. Chelidonine; (+)-Chelidonine; Chelidonin; Chelidoniny; Helidonine; Khelidonin; Stylophorin;

CHELIDONINE

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PRODUCT IDENTIFICATION

CAS RN

476-32-4 (net), 4312-31-6 (HCl)

EINECS RN

207-504-1

FORMULA

C20H19NO5

MOLE WEIGHT

353.37

H.S CODE

2939.99.0000

SMILES

c12[C@@H]3[C@@H](c4c(c5c(OCO5)cc4)C[N@@]3C)[C@@H](Cc1cc1O C Oc1c2)O

CLASSIFICATION

Alkaloid, Benzophenanthridine

EXTRA NOTES

Inhibits tubulin polymerisation (IC50=24 μM), thereby disrupting microtubule structure in cells and inducing a G2/M mitotic arrest. sigmaaldrich

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

135 ~ 136 C

BOILING POINT

220 C

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

 

VAPOR PRESSURE

 

AUTOIGNITION TEMP

 
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Chelidonine

Wikipedia Linking - Chelidonine

Google Scholar Search - Chelidonine

U.S. National Library of Medicine - Chelidonine

PubChem Compound Summary - Chelidonine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Chelidonine

ChEBI (http://www.ebi.ac.uk/chebi/) -  Chelidonine

NCBI (http://www.ncbi.nlm.nih.gov/) -  Chelidonine

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

98% min

MELTING POINT

135 ~ 136 C

WATER

5.0% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Oral), Acute toxicity (Inhalation), Acute toxicity (Dermal). Hazard statements: Harmful if swallowed or in contact with skin. Harmful if inhaled.

SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H302 + H312-H332

P STATEMENTS

P280

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

20/21/22

SAFETY PHRASES

36/37

 

PACKING

Preserve in light-resistant and well-closed containers