|
CHELIDONINE |
| Synonyms. Chelidonine; (+)-Chelidonine; Chelidonin; Chelidoniny; Helidonine; Khelidonin; Stylophorin; |
|
|
| PRODUCT IDENTIFICATION | |
|
CAS RN |
476-32-4 (net), 4312-31-6 (HCl) |
|
EINECS RN |
207-504-1 |
|
FORMULA |
C20H19NO5 |
|
MOLE WEIGHT |
353.37 |
|
H.S CODE |
2939.99.0000 |
|
SMILES |
c12[C@@H]3[C@@H](c4c(c5c(OCO5)cc4)C[N@@]3C)[C@@H](Cc1cc1O C Oc1c2)O |
|
CLASSIFICATION |
Alkaloid, Benzophenanthridine |
|
EXTRA NOTES |
Inhibits tubulin polymerisation (IC50=24 μM), thereby disrupting microtubule structure in cells and inducing a G2/M mitotic arrest. sigmaaldrich |
|
|
| PHYSICAL AND CHEMICAL PROPERTIES | |
|
PHYSICAL STATE. |
white to off-white crystalline powder |
|
MELTING POINT |
135 ~ 136 C |
|
BOILING POINT |
220 C |
|
DENSITY |
|
|
SOLUBILITY IN WATER |
|
| SOLVENT SOLUBILITY |
|
|
VAPOR DENSITY |
|
|
log P(octanol-water) |
|
|
VAPOR PRESSURE |
|
|
AUTOIGNITION TEMP |
|
| pK |
|
|
REFRACTIVE INDEX |
|
|
FLASH POINT |
|
|
|
| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
|
INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
|
NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
|
|
| EXTERNAL LINKS & GENERAL DESCRIPTION |
|
USA.gov - Chelidonine Wikipedia Linking - Chelidonine Google Scholar Search - Chelidonine U.S. National Library of Medicine - Chelidonine PubChem Compound Summary - Chelidonine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Chelidonine ChEBI (http://www.ebi.ac.uk/chebi/) - Chelidonine NCBI (http://www.ncbi.nlm.nih.gov/) - Chelidonine |
|
|
| SALES SPECIFICATION | |
|
APPEARANCE |
white to off-white crystalline powder |
|
ASSAY |
98% min |
|
MELTING POINT |
135 ~ 136 C |
|
WATER |
5.0% max |
|
|
| TRANSPORT & REGULATORY INFORMATION | |
|
UN NO. |
|
| HAZARD CLASS |
|
| PACKING GROUP | |
|
|
| SAFETY INFORMATION | |
|
HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Oral), Acute toxicity (Inhalation), Acute toxicity (Dermal). Hazard statements: Harmful if swallowed or in contact with skin. Harmful if inhaled. |
| SIGNAL WORD | Warning |
|
PICTOGRAMS |
|
|
HAZARD STATEMENTS |
H302 + H312-H332 |
|
P STATEMENTS |
P280 |
| EC DIRECTIVES |
|
| HAZARD CODES |
|
|
RISK PHRASES |
20/21/22 |
|
SAFETY PHRASES |
36/37 |
|
|
| PACKING |
|
Preserve in light-resistant and well-closed containers |
|
|