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CINCHONINE |
| Synonyms. Cinchonine; (+)-Cinconine; (8R,9S)-Cinchonine; (9S)-Cinchonan-9-ol; alpha-(5-Vinyl-2-quinolyl)-2-quinuclidinemethanol; alpha-4-Quinolyl-5-vinyl-2-quinuclidinemethanol; D-Cinchonine; alpha-(5-Vinyl-2-quinuclidinyl)-4-quinolinemethanol; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
118-10-5 |
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EINECS RN |
204-234-6 |
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FORMULA |
C19H22N2O |
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MOLE WEIGHT |
294.39 |
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H.S CODE |
2939.20.0050 |
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SMILES |
C1(N2C[C@@H](C(C1)CC2)C=C)[C@H](c1c2c(ncc1)cccc2)O |
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CLASSIFICATION |
Alkaloid, Quinuclidine |
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EXTRA NOTES |
Diastereoisomer of cinchonidine with distinct physiochemical properties; occurs in most varieties of cinchona bark. |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
265 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
240 mg/l |
| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
2.68 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Cinchonine Wikipedia Linking - Cinchonine Google Scholar Search - Cinchonine U.S. National Library of Medicine - Cinchonine PubChem Compound Summary - Cinchonine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Cinchonine ChEBI (http://www.ebi.ac.uk/chebi/) - Cinchonine NCBI (http://www.ncbi.nlm.nih.gov/) - Cinchonine EPA - Substance Registry Services - Cinchonine |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
85% min |
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MELTING POINT |
260 ~ 265 C |
| OPTICAL ROTATION |
+223° ~ +227° (c=0.6, EtOH) |
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LOSS ON DRYING |
1% max |
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DIHYDROCINCHONINE |
15% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Inhalation). Hazard statements: Harmful if swallowed or if inhaled. |
| SIGNAL WORD | Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H302-H332 |
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P STATEMENTS |
P261-P305 + P351 + P338 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
20/22 |
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SAFETY PHRASES |
26-36 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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