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COLFORSIN |
| Synonyms. Colforsin; (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-Dodecahydro-5,6,10,10b-tetrahydroxy-3,4a,7,7, 10a-pentamethyl- 3-vinyl-1H-naphtho(2,1-b)pyran-1-one 5-acetate; (3R-(3alpha,4abeta,5beta,6beta ,6aalpha, 10alpha,10abeta,10balpha))- 5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy- 3,4a,7,7, 10a-pentamethyl-1H-naphtho (2,1-b)pyran-1-one; 7-beta-Acetoxy-8,13-epoxy-1-alpha,6- beta,9-alpha- trihydroxylabd-14-en-11-one; Boforsin; Coleonol; Colforsin; Colforsina; Colforsine; Colforsinum; Forskolin; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
66575-29-9 |
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EINECS RN |
266-410-9 |
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FORMULA |
C22H34O7 |
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MOLE WEIGHT |
410.50 |
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H.S CODE |
2932.99.9090 |
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SMILES |
[C@]12([C@@]3([C@@H]([C@@H]([C@@H]([C@]1(O[C@](CC2=O)(C=C) C)C)OC(=O)C)O) C(CC[C@@H]3O)(C)C)C)O |
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CLASSIFICATION |
Antitumor agent |
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EXTRA NOTES |
Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant Coleus forskohlii. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland. MeSH |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE |
white to brown crystalline powder |
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MELTING POINT |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 1, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Colforsin Wikipedia Linking - Colforsin Google Scholar Search - Colforsin U.S. National Library of Medicine - Colforsin PubChem Compound Summary - Colforsin Drug Bank - Colforsin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Colforsin ChEBI (http://www.ebi.ac.uk/chebi/) - Colforsin NCBI (http://www.ncbi.nlm.nih.gov/) - Colforsin Material Safety Data Sheet - Colforsin Human Metabolome Database - Colforsin Biochem/physiol Actions: Cell-permeable diterpenoid that possesses anti-hypertensive, positive inotropic, and adenylyl cyclase activating properties. Many of its biological effects are due to its activation of adenylyl cyclase and the resulting increase in intracellular cAMP concentration. Forskolin effects calcium currents and inhibits MAP kinase. sigmaaldrich |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to brown crystalline powder |
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ASSAY |
98% min |
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LOSS ON DRYING |
1% max |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Dermal). |
| SIGNAL WORD | Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H312 |
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P STATEMENTS |
P280 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
21 |
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SAFETY PHRASES |
22-36/37 |
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| PACKING |
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Preserved in light-resistant and well-closed bottles |
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