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CONESSINE |
| Synonyms. Conessine; (3-beta)-N,N-Dimethylcon-5-enin-3-amine; 3beta-(Dimethylamino)con-5-ene; Conesina; Conessin; Conessinum; Konessin; Neriine; Roquessine; Wrightine; 3beta-(Dimethylamino)con-5-enine; N,18-Dihydrotrimethylconkurchine; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
546-06-5 |
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EINECS RN |
208-897-2 |
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FORMULA |
C24H40N2 |
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MOLE WEIGHT |
356.59 |
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H.S CODE |
2939.99.0000 |
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SMILES |
C1[C@@]23[C@@H](CC[C@@H]2[C@@H]2CC=C4[C@@](CC[C@@H] (N(C) C)C4) ([C@@H]2CC3)C) [C@@H](C)[N@@]1C |
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CLASSIFICATION |
Alkaloid |
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EXTRA NOTES |
Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. The molecule also binds to the human α2C4 adrenergic receptor (pKi = 7.98). sigmaaldrich |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
125 ~ 126 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
5.14 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Conessine Wikipedia Linking - Conessine Google Scholar Search - Conessine U.S. National Library of Medicine - Conessine PubChem Compound Summary - Conessine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Conessine ChEBI (http://www.ebi.ac.uk/chebi/) - Conessine NCBI (http://www.ncbi.nlm.nih.gov/) - Conessine |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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MELTING POINT |
125 ~ 126 C |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Hazard statements: Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| SIGNAL WORD | Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H315-H319-H335 |
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P STATEMENTS |
P261-P305 + P351 + P338 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
36/37/38 |
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SAFETY PHRASES |
26 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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