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COSTUNOLIDE |
| Synonyms. Costunolide; (E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone; Costunlide; Costunolid; Costus lactone; (3aS-(3aR*,6E,10E,11aS*))- 3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylenecyclodeca(b)furan-2(3H)-one; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
553-21-9 |
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EINECS RN |
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FORMULA |
C15H20O2 |
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MOLE WEIGHT |
232.32 |
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H.S CODE |
2932.20.5050 |
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SMILES |
C1(C([C@@H]2CCC(=CCCC(=C[C@@H]2O1)C)C)=C)=O |
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CLASSIFICATION |
Sesquiterpene lactone |
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EXTRA NOTES |
Wood oil from tree Eremanthus elaegnus used as chemoprophylactic agent in schistosomiasis |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE |
white powder |
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MELTING POINT |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Costunolide Wikipedia Linking - Costunolide Google Scholar Search - Costunolide U.S. National Library of Medicine - Costunolide PubChem Compound Summary - Costunolide KEGG (Kyoto Encyclopedia of Genes and Genomes) - Costunolide ChEBI (http://www.ebi.ac.uk/chebi/) - Costunolide NCBI (http://www.ncbi.nlm.nih.gov/) - Costunolide Human Metabolome Database - Costunolide Biochem/physiol Actions: Costunolide is a sesquiterpene lactone originally isolated from plants widely used in many herbal medicines. It has a variety of effects. Costunolide is a potent inducer of apoptosis, a potent anti-cancer agent, has anti-inflammatory, anti-viral, anti-fungal, antimycobacterial activity and has been shown to inhibit telomerase activity. sigmaaldrich |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Skin irritation, Eye irritation, Skin sensitization, Specific target organ toxicity. |
| SIGNAL WORD | Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H315-H319-H335 |
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P STATEMENTS |
P261-P280-P305 + P351 + P338 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
36/37/38 |
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SAFETY PHRASES |
26 |
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| PACKING |
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Preserved in light-resistant and well-closed bottles |
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