Cyclo(-Gly-Pro)

Synonyms. Cyclo(-Gly-Pro); (S)-3,6-Dioxohexahydropyrrolo[1,2-a]pyrazine; Glycyl-L-proline lactam; Cyclo-Glycyl-L-Proline; (s)-1,4-Dioxoperhydropyrrolo [1,2-a]pyrazine; (8aS)-Hexahydropyrrolo[1,2-a] pyrazine- 1,4-dione; (8aS)-Hexahydropyrrolo[1,2-a]piperazine-1,4-dione; (8aS)-Octahydropyrrolo[1,2-a ]piperazine-1,4-dione; (s)-Hexahydropyrrolo [1, 2-a] pyrazine-1,4-dione; (s)-Hexahydropyrrolo [1,2-a] pyrazine-1,4-dione; (S)-Hexahydropyrrolo(1,2-a)pyrazine-1,4-dione-4-17O; (8aS)-2,3,6,7,8,8a- Hexahydropyrrolo[1,2-a]pyrazine-1,4-dione; Cyclo(Pro-O-Gly); Cyclo(prolyl-glycyl); Cyclo(prolylglycyl); Cycloprolylglycine;

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PRODUCT IDENTIFICATION

CAS RN

3705-27-9

EINECS RN

 

FORMULA

 C7H10N2O2

MOLE WEIGHT

154.17

H.S CODE

 2933.59.9500

SMILES

 C1C[C@H]2C(=O)NCC(=O)N2C1

CLASSIFICATION

 

EXTRA NOTES

 

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

220 ~ 223 C

BOILING POINT

 

DENSITY

1.32

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents, Strong acids, Strong bases

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Cyclo(-Gly-Pro)

Google Scholar Search - Cyclo(-Gly-Pro)

PubChem Compound Summary - Cyclo(-Gly-Pro)

NCBI (http://www.ncbi.nlm.nih.gov/) -  Cyclo(-Gly-Pro)

SIGMA-ALDRICH
Biochem/physiol Actions Cyclo-Gly-Pro is a neuro-protective compound, an endogenous diketopiperazine, which enhances memory. In the animal model of PD, the compound improved functional recovery when administered after the onset of dyskinesia. It appears that the compound recovery function may result from non-proliferative neurogenesis that results from the inhibition of apoptosis of stem cells and/or the promotion of neuronal-orientated proliferation in the SVZ (subventricular zone).

 

SALES SPECIFICATION

APPEARANCE

white to off-white powder

ASSAY

98% min

MELTING POINT

220 ~ 223 C

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

Not a hazardous substance.

 

PACKING

Preserve in light-resistant and well-closed containers

 

PRICE INFORMATION