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EPLERENONE |
| Synonyms. Eplerenone; Epoxymexrenone; nspra; Selara; 9,11alpha-Epoxy-17-hydroxy-3-oxo- 17alpha-pregn-4-ene-7alpha, 21-dicarboxylic acid gamma-lactone methyl ester; (7alpha,11alpha,17alpha)-Pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo- gamma-lactone methyl ester; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
107724-20-9 |
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EINECS RN |
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FORMULA |
C24H30O6 |
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MOLE WEIGHT |
414049 |
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H.S CODE |
2932.20.2000 |
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SMILES |
C[C@]12CCC(=O)C=C1C[C@H]([C@@H]3[C@]24[C@H](O4)C[C@]5 ([C@H]3CC[@@]56CCC(=O)O6)C)C(=O)OC |
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CLASSIFICATION |
Aldosterone Antagonist, Diuretics, Hormone, Natriuretic Agent |
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EXTRA NOTES |
Eplerenone is a selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerenone is used in the treatment of hypertension and congestive heart failure. http://pubchem.ncbi.nlm.nih.gov/ |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
240 ~ 242 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
very Slightly soluble |
| SOLVENT SOLUBILITY |
Soluble in dichloromethane, acetonitrile, DMSO. Slightly soluble in ethanol, sparingly soluble in MEK, methanol. |
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VAPOR DENSITY |
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log P(octanol-water) |
7.1 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 0, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Eplerenone Wikipedia Linking - Eplerenone Google Scholar Search - Eplerenone U.S. National Library of Medicine - Eplerenone PubChem Compound Summary - Eplerenone IPCS INCHEM - Eplerenone Drug Bank - Eplerenone KEGG (Kyoto Encyclopedia of Genes and Genomes) - Eplerenone ChEBI (http://www.ebi.ac.uk/chebi/) - Eplerenone NCBI (http://www.ncbi.nlm.nih.gov/) - Eplerenone Material Safety Data Sheet - Eplerenone Human Metabolome Database - Eplerenone Hazardous Substances Data Bank - Eplerenone EPA - Substance Registry Services - Eplerenone |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
99% min |
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MELTING POINT |
240 ~ 242 C |
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OPTICAL ACTIVITY |
+4° ~ +6° (in chloroform) |
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LOSS ON DRYING |
0.5% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
Not a hazardous substance. |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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