ETHYL INDOLE-2-CARBOXYLATE

Synonyms. Ethyl indole-2-carboxylate; 1H-Indole-2-carboxylic acid ethyl ester; 2-Carbethoxyindole; Ethyl 1H-indole-2-carboxylate; 2-(Ethoxycarbonyl)-1H-indole;

ETHYL INDOLE-2-CARBOXYLATE

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PRODUCT IDENTIFICATION

CAS RN

3770-50-1

EINECS RN

223-206-4

FORMULA

 C11H11NO2

MOLE WEIGHT

189.21

H.S CODE

 2933.99.7900

SMILES

 c1([nH]c2ccccc2c1)C(=O)OCC

CLASSIFICATION

Indole

EXTRA NOTES

 

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to yellow crystalline powder

MELTING POINT

122 ~ 125 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 1, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Ethyl indole-2-carboxylate

Google Scholar Search - Ethyl indole-2-carboxylate

PubChem Compound Summary - Ethyl indole-2-carboxylate

NCBI (http://www.ncbi.nlm.nih.gov/) -  Ethyl indole-2-carboxylate

http://www.sigmaaldrich.com
Application
Reactant for preparation of:
·CRTH2 receptor antagonists
·Indoleamine 2,3-dioxygenase (IDO) inhibitors
·Cannabinoid CB1 receptor antagonists
·Inhibitors of Human Reticulocyte 15-Lipoxygenase-1
·N-(benzoylphenyl)-1H-indole-2-carboxamides as potent antihypertriglyceridemic agents
·A antiproliferative agent against human leukemia K562 cells
·Inhibitors of p38 MAP kinase
·Acetolactate synthase inhibitors

 

SALES SPECIFICATION

APPEARANCE

white to yellow crystalline powder

ASSAY

99.0% min

MELTING POINT

119 ~ 125 C

HEAVY METALS

10ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Not a dangerous substance. Potential Health Effects: Eyes - May cause eye irritation. Skin - May be harmful if absorbed through skin May cause skin irritation. Inhalation - May be harmful if inhaled. May cause respiratory tract irritation. Ingestion - May be harmful if swallowed.

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 

 

PACKING

Preserved in light-resistant and well-closed bottles

 

PRICE INFORMATION