GAMBOGIC ACID

Synonyms. Gambogic acid; B''-Guttiferin; beta-Guttiferin; Cambogic acid; (Z)-4-((1S,3aR,5S,11R, 14aS)- 8-Hydroxy-2,2,11-trimethyl-13-(3-methylbut-2-en-1-yl) -11-(4-methylpent-3-en- 1-yl)-4,7-dioxo- 2,3a,4,5,7,11 -hexahydro-1H-1,5-methanofuro[3,2-g]pyrano [3,2-b]xanthen-3a-yl) -2-methylbut-2-enoic acid; 1,5-Methano-1H,3H,11H-furo(3,4-g)pyrano(3,2-b)xanthene-1-crotonic acid; Beta-Guttilactone; Guttatic acid; Guttic acid;

GAMBOGIC ACID

 

PRODUCT IDENTIFICATION

CAS RN

2752-65-0

EINECS RN

 

FORMULA

C38H44O8

MOLE WEIGHT

628.75

H.S CODE

 2918.99.3000

SMILES

 O=C1/C4=C/[C@H]6C(=O)[C@@]5(OC([C@@H]([C@]45Oc3c1c(O)c 2\C=C/[C@@](Oc2c3C\C=C(/C)C)(C)CC\C=C(/C)C)C6)(C)C)C/C =C(\C(=O)O)C

CLASSIFICATION

Xanthonoid

EXTRA NOTES

Biochem/physiol Actions:Gambogic acid acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle. sigmaaldrich
Principal acidic component of gamboge from the latex of Garcinia hanburyi

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

Orange solid

MELTING POINT

 

BOILING POINT

 

DENSITY

1.29

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

Soluble in DMSO, ethanol

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Gambogic acid

Wikipedia Linking - Gambogic acid

Google Scholar Search - Gambogic acid

U.S. National Library of Medicine - Gambogic acid

PubChem Compound Summary - Gambogic acid

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Gambogic acid

ChEBI (http://www.ebi.ac.uk/chebi/) -  Gambogic acid

NCBI (http://www.ncbi.nlm.nih.gov/) -  Gambogic acid

 

SALES SPECIFICATION

APPEARANCE

Orange solid

ASSAY

98% min

OPTICAL ACTIVITY

-685° (methanol)

LOSS ON DRYING

0.5% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

2811

HAZARD CLASS

6.1

PACKING GROUP III

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Hazard statements: Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

SIGNAL WORD Danger

PICTOGRAMS

HAZARD STATEMENTS

H301 Toxic if swallowed.
H315 Causes skin irritation.
H319 Causes serious eye irritation.
H335 May cause respiratory irritation.

PRECAUTIONARY STATEMENTS

P261 Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
P264 Wash skin thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/ eye protection/ face protection.
P301 + P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302 + P352 IF ON SKIN: Wash with plenty of soap and water.
P304 + P340 IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P312 Call a POISON CENTER or doctor/ physician if you feel unwell.
P321 Specific treatment (see supplemental first aid instructions on this label). P330 Rinse mouth.
P332 + P313 If skin irritation occurs: Get medical advice/ attention.
P337 + P313 If eye irritation persists: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P403 + P233 Store in a well-ventilated place. Keep container tightly closed.
P405 Store locked up.
P501 Dispose of contents/ container to an approved waste disposal plant.

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

25:Toxic if swallowed
36/37/38:Irritating to eyes, respiratory system and skin

SAFETY PHRASES

26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
45: In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)

 

PACKING

Preserve in light-resistant and well-closed containers

 

PRICE INFORMATION