GRISEOFULVIN

Synonyms. Griseofulvin; Griscofulvin; Grisefuline; Griseofulvin; Griseofulvine; Griseofulvinum; Likuden; Murfulvin; Spirofulvin; (1'S,6'R)-7-Chloro-2',4,6-trimethoxy- 6'-methylspiro(benzofuran-2 (3H),1'- (2)cyclohexene)- (ene)-3,4'-dione3,4'-dione; (1'S,6'R)-7-Chloro- 2',4,6-trimethoxy-6'- methylspiro (benzofuran- 2(3H),1'-(2)cyclohexene)-3,4'-dione; (1'S-trans)- 7-Chloro-2',4,6-trimethoxy-6'- methylspiro(benzofuran-2(3H),1'-cyclohex-2'-ene)-3,4'-dione; (2S-trans)-7-Chloro-2',4,6-trimethoxy- 6'-methyl spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione; 1'S-trans)- 7-Chloro-2',4,6-trimethoxy -6'-methylspiro(benzofuran-2(3H), 1'-cyclohex-2'-ene)-3,4'-dione; 7-Chloro-2',4,6-trimethoxy- 6'beta-methylspiro(benz fouran-2(3H),1'-(2)cyclohexene)-3,4'-dione; 7-Chloro-4,6,2'-trimethoxy- 6'-methylgris-2'-en-3,4'-dione; 7-Chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'- methylcyclohex-2'-en-4'-one); Amudane; Delmofulvina; Fulcin; Fulvicin; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin; Gresfeed; Gricin; Grifulin; Grifulvin; Grifulvin V; Grisactin; Grisactin V;

GRISEOFULVIN

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

126-07-8

EINECS RN

204-767-4

FORMULA

C17H17ClO6

MOLE WEIGHT

352.77

H.S CODE

2941.90.1050

SMILES

C1([C@@]2(Oc3c(c(OC)cc(OC)c13)Cl)C(=CC(=O)C[C@H]2C)OC)=O

CLASSIFICATION

Antifungal antibiotic

EXTRA NOTES

Antifungal. Mode of action: Disrupts the mitotic spindle structure and inhibits nuclear division.1 Induces apoptosis in human tumor cell lines

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE

white to off-white crystalline powder

MELTING POINT

220 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

2.18

VAPOR PRESSURE

 

AUTOIGNITION TEMP

 
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents.

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Griseofulvin

Wikipedia Linking - Griseofulvin

Google Scholar Search - Griseofulvin

U.S. National Library of Medicine - Griseofulvin

PubChem Compound Summary - Griseofulvin

Drug Bank -  Griseofulvin

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Griseofulvin

ChEBI (http://www.ebi.ac.uk/chebi/) -  Griseofulvin

NCBI (http://www.ncbi.nlm.nih.gov/) -  Griseofulvin

Material Safety Data Sheet - Griseofulvin

Human Metabolome Database - Griseofulvin

Hazardous Substances Data Bank - Griseofulvin

EPA - Substance Registry Services - Griseofulvin

 

SALES SPECIFICATION

APPEARANCE

white to off-white crystalline powder

ASSAY

98% min

MELTING POINT

218 ~ 220 C

HEAVY METALS

10ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Skin sensitization; Carcinogenicity; Reproductive toxicity

SIGNAL WORD Danger

PICTOGRAMS

PICTOGRAM_GHS08_health.jpgPICTOGRAM_GHS07_exclamation.jpg

HAZARD STATEMENTS

H317-H351-H360

P STATEMENTS

P201-P280-P308 + P313

EC DIRECTIVES

 

HAZARD CODES

CODE_T_T+_toxic_very_toxic.gif

RISK PHRASES

40-43-60-61

SAFETY PHRASES

22-36/37/39-45

 

PACKING

Preserved in light-resistant and well-closed bottles