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GRISEOFULVIN |
| Synonyms. Griseofulvin; Griscofulvin; Grisefuline; Griseofulvin; Griseofulvine; Griseofulvinum; Likuden; Murfulvin; Spirofulvin; (1'S,6'R)-7-Chloro-2',4,6-trimethoxy- 6'-methylspiro(benzofuran-2 (3H),1'- (2)cyclohexene)- (ene)-3,4'-dione3,4'-dione; (1'S,6'R)-7-Chloro- 2',4,6-trimethoxy-6'- methylspiro (benzofuran- 2(3H),1'-(2)cyclohexene)-3,4'-dione; (1'S-trans)- 7-Chloro-2',4,6-trimethoxy-6'- methylspiro(benzofuran-2(3H),1'-cyclohex-2'-ene)-3,4'-dione; (2S-trans)-7-Chloro-2',4,6-trimethoxy- 6'-methyl spiro(benzofuran-2(3H),1'-(2)cyclohexene)-3,4'-dione; 1'S-trans)- 7-Chloro-2',4,6-trimethoxy -6'-methylspiro(benzofuran-2(3H), 1'-cyclohex-2'-ene)-3,4'-dione; 7-Chloro-2',4,6-trimethoxy- 6'beta-methylspiro(benz fouran-2(3H),1'-(2)cyclohexene)-3,4'-dione; 7-Chloro-4,6,2'-trimethoxy- 6'-methylgris-2'-en-3,4'-dione; 7-Chloro-4,6-dimethoxycoumaran-3-one-2-spiro-1'-(2'-methoxy-6'- methylcyclohex-2'-en-4'-one); Amudane; Delmofulvina; Fulcin; Fulvicin; Fulvina; Fulvinil; Fulvistatin; Fungivin; Greosin; Gresfeed; Gricin; Grifulin; Grifulvin; Grifulvin V; Grisactin; Grisactin V; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
126-07-8 |
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EINECS RN |
204-767-4 |
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FORMULA |
C17H17ClO6 |
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MOLE WEIGHT |
352.77 |
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H.S CODE |
2941.90.1050 |
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SMILES |
C1([C@@]2(Oc3c(c(OC)cc(OC)c13)Cl)C(=CC(=O)C[C@H]2C)OC)=O |
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CLASSIFICATION |
Antifungal antibiotic |
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EXTRA NOTES |
Antifungal. Mode of action: Disrupts the mitotic spindle structure and inhibits nuclear division.1 Induces apoptosis in human tumor cell lines |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE |
white to off-white crystalline powder |
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MELTING POINT |
220 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
2.18 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Griseofulvin Wikipedia Linking - Griseofulvin Google Scholar Search - Griseofulvin U.S. National Library of Medicine - Griseofulvin PubChem Compound Summary - Griseofulvin Drug Bank - Griseofulvin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Griseofulvin ChEBI (http://www.ebi.ac.uk/chebi/) - Griseofulvin NCBI (http://www.ncbi.nlm.nih.gov/) - Griseofulvin Material Safety Data Sheet - Griseofulvin Human Metabolome Database - Griseofulvin Hazardous Substances Data Bank - Griseofulvin EPA - Substance Registry Services - Griseofulvin |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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MELTING POINT |
218 ~ 220 C |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Skin sensitization; Carcinogenicity; Reproductive toxicity |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H317-H351-H360 |
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P STATEMENTS |
P201-P280-P308 + P313 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
40-43-60-61 |
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SAFETY PHRASES |
22-36/37/39-45 |
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| PACKING |
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Preserved in light-resistant and well-closed bottles |