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HYOSCYAMINE |
| Synonyms. Hyoscyamine; (-)-Atropine; (-)-Hyoscyamine; (S)-(-)-Hyoscyamine; (S)-Atropine; 1-Hyoscyamine; 1alphaH,5alphaH-Tropan-3alpha-ol (-)-tropate; Cystospaz; Daturine; Duboisine; Hyospaz; Hyosyne; L-Hyoscyamine; L-Tropine tropate; Tropine, (-)-tropate; (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl) 3-hydroxy-2-phenylpropanoate; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
101-31-5 (free base), 306-03-6 (HCl) |
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EINECS RN |
202-933-0 |
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FORMULA |
C17H23NO3 |
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MOLE WEIGHT |
289.37 |
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H.S CODE |
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SMILES |
[C@@H]1(CC2N(C(C1)CC2)C)OC(=O)[C@H](c1ccccc1)CO |
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CLASSIFICATION |
Anticholinergic, Tropane alkaloid, Oneirogen |
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EXTRA NOTES |
Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)
Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson’s disease, as well as for control of respiratory secretions in end of life care. DrugBank |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
108 ~ 109 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
1.91 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
11.72 |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 3, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Hyoscyamine Wikipedia Linking - Hyoscyamine Google Scholar Search - Hyoscyamine U.S. National Library of Medicine - Hyoscyamine PubChem Compound Summary - Hyoscyamine Drug Bank - Hyoscyamine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Hyoscyamine ChEBI (http://www.ebi.ac.uk/chebi/) - Hyoscyamine NCBI (http://www.ncbi.nlm.nih.gov/) - Hyoscyamine Hazardous Substances Data Bank - Hyoscyamine EPA - Substance Registry Services - Hyoscyamine |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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MELTING POINT |
108 ~ 109 C |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
1544 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | II |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
Highly Toxic (USA) Very Toxic (EU). Very toxic by inhalation and if swallowed. Target organ(s): Central nervous system. Peripheral nervous system. |
| HAZARD CODES |
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RISK PHRASES |
26/28 |
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SAFETY PHRASES |
24-45 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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