LACTULOSE

Synonyms. Lactulose; 4-O-beta-D-Galactopyranosyl-D-fructofuranose; 4-O-beta-D-Galactopyranosyl-D-fructose; 4-O-beta-D-Galattopiranosil-D-fruttofuranosio; Lactulosa; Lactulosum; (2S,3R,4S,5R,6R)-2-((2R,3S,4S,5R)-4,5-Dihydroxy-2,5-bis(hydroxymethyl) tetrahydrofuran -3-yloxy)- 6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol;

LACTULOSE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

4618-18-2

EINECS RN

225-027-7

FORMULA

C12H22O11

MOLE WEIGHT

342.30

H.S CODE

 2940.00.6000

SMILES

 O([C@@H]1[C@H](O[C@@]([C@H]1O)(CO)O)CO)[C@@H]1O[C@@H ]([C@ H]( O)[C@@H]([C@H]1O)O)CO

CLASSIFICATION

Carbohydrate, Disaccharide, Laxative

EXTRA NOTES

A synthetic disaccharide used in the treatment of constipation and hepatic encephalopathy. It has also been used in the diagnosis of gastrointestinal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p887) [From MeSH]
ATC code: A06AD11
Other RN: 576-08-9, 29319-45-7, 33980-82-4, 40773-84-0

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

white to off-white crystalline powder

MELTING POINT

169 ~ 171 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

 -4.68

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 0, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Lactulose

Wikipedia Linking - Lactulose

Google Scholar Search - Lactulose

U.S. National Library of Medicine - Lactulose

PubChem Compound Summary - Lactulose

Drug Bank -  Lactulose

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Lactulose

http://www.ebi.ac.uk/chebi/ -  Lactulose

http://www.ncbi.nlm.nih.gov/ -  Lactulose

EPA - Substance Registry Services - Lactulose

http://www.sigmaaldrich.com/
Application: Lactulose, a disaccharide composed of fructose and galactose units, is used as an osmolyte that relieves constipation and supports probiotic processes in the intestine and colon. Lactulose helps stabilize blood glucose and insulin levels.

 

SALES SPECIFICATION

APPEARANCE

white crystalline powder

ASSAY

98% min

MELTING POINT

169 ~ 171 C

OPTICAL ROTATION

-48° ~ -52° (c=1, water)

LOSS ON DRYING

1% max

HEAVY METALS

10ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Not a dangerous substance. Potential Health Effects: Eyes - May cause eye irritation. Skin - May be harmful if absorbed through skin May cause skin irritation. Inhalation - May be harmful if inhaled. May cause respiratory tract irritation. Ingestion - May be harmful if swallowed.

HAZARD CODES

 

RISK PHRASES

 

SAFETY PHRASES

 

 

PACKING

Preserved in light-resistant and well-closed bottles