LAUDANOSINE

Synonyms. Laudanosine; 1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinoline; (+-)-Laudanosine; -methyltetrahydropapaverine; (1)-1-((3,4-Dimethoxyphenyl)methyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinoline; (1S)-1-[(3,4-Dimethoxyphenyl)methyl]-6,7-dimethoxy- 2-methyl-3,4-dihydro-1H-isoquinoline;

LAUDANOSINE

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PRODUCT IDENTIFICATION

CAS RN

1699-51-0

EINECS RN

216-923-9

FORMULA

C21H27NO4

MOLE WEIGHT

357.44

H.S CODE

 

SMILES

c12[C@@H](Cc3cc(c(OC)cc3)OC)[N@@](CCc1cc(OC)c(c2)OC)C

CLASSIFICATION

Tetrahydroisoquinoline, Alkaloid

EXTRA NOTES

Laudanosine or N-methyltetrahydropapaverine is a recognized metabolite[1] of atracurium and cisatracurium. Laudanosine decreases the seizure threshold, and thus it can induce seizures if present at sufficient threshold concentrations; however such concentrations are unlikely to be produced consequent to chemodegradable metabolism of clinically administered doses of cisatracurium or atracurium. wikipedia

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

yellow powder

MELTING POINT

89 C

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

 

VAPOR PRESSURE

 

AUTOIGNITION TEMP

 
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Laudanosine

Wikipedia Linking - Laudanosine

Google Scholar Search - Laudanosine

U.S. National Library of Medicine - Laudanosine

PubChem Compound Summary - Laudanosine

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Laudanosine

NCBI (http://www.ncbi.nlm.nih.gov/) -  Laudanosine

 

SALES SPECIFICATION

APPEARANCE

yellow powder

ASSAY

98% min

MELTING POINT

87 ~ 89 C

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

PACKING

Preserve in light-resistant and well-closed containers