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LOBELINE |
| Synonyms. Lobeline; 2-(6-(beta-Hydroxyphenethyl)-1-methyl-2-piperidyl)acetophenone; (-)-Lobeline; 2-(6-(2-Hydroxy-2-phenylethyl)-1-methyl-2-piperidinyl)-1-phenylethanone; 8,10-Diphenyllobelionol; Inflatine; Lobelin; Lobelina; Lobelinum; L-Lobeline; alpha-Lobeline; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
90-69-7 (free base), 134-63-4 (HCl), 134-64-5 (Sulfate) |
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EINECS RN |
202-012-3 (free base), 205-150-2 (HCl) |
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FORMULA |
C22H27NO2 |
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MOLE WEIGHT |
337.46 |
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H.S CODE |
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SMILES |
C([C@H]1[N@@]([C@@H](CC(c2ccccc2)=O)CCC1)C)[C@H](c1ccccc1)O |
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CLASSIFICATION |
Alkaloid, Piperidine, Nicotinic agonist, Ganglionic Stimulant |
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EXTRA NOTES |
An alkaloid that has actions similar to NICOTINE on nicotinic cholinergic receptors but is less potent. It has been proposed for a variety of therapeutic uses including in respiratory disorders, peripheral vascular disorders, insomnia, and smoking cessation. MeSH |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
130 ~ 131 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
3.74 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Lobeline Wikipedia Linking - Lobeline Google Scholar Search - Lobeline U.S. National Library of Medicine - Lobeline PubChem Compound Summary - Lobeline Drug Bank - Lobeline KEGG (Kyoto Encyclopedia of Genes and Genomes) - Lobeline ChEBI (http://www.ebi.ac.uk/chebi/) - Lobeline NCBI (http://www.ncbi.nlm.nih.gov/) - Lobeline |
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| SALES SPECIFICATION (HCl) | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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MELTING POINT |
128 ~ 132 C |
| OPTICAL ROTATION |
-56° ~ -58° (c=2, water) |
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LOSS ON DRYING |
1% max |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
1544 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | III |
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| SAFETY INFORMATION (HCl) | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Inhalation). Hazard statements: Toxic if swallowed or if inhaled. |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H301-H331 |
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P STATEMENTS |
P261-P301 + P310-P311 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
23/25 |
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SAFETY PHRASES |
36/37/39-45 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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