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METRONIDAZOLE |
| Synonyms. Metronidazole; 1-(2-Hydroxy-1-ethyl)-2-methyl-5-nitroimidazole; 1-(2-Hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(beta-Ethylol)-2-methyl-5-nitro-3-azapyrrole; 1-(beta-Hydroxyethyl)-2-methyl-5-nitroimidazole; 1-(beta-Oxyethyl)-2-methyl-5-nitroimidazole; 2-Methyl-1-(2-hydroxyethyl)-5-nitroimidazole; 2-Methyl-3-(2-hydroxyethyl)-4-nitroimidazole 2-Methyl-5-nitroimidazole-1-ethanol; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
443-48-1 |
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EINECS RN |
207-136-1 |
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FORMULA |
C6H9N3O3 |
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MOLE WEIGHT |
171.15 |
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H.S CODE |
2933.29.9000 |
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SMILES |
Cc1ncc(n1CCO)[N+](=O)[O-] |
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CLASSIFICATION |
Anti-infective, Antiparasitic, Antiprotozoal |
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EXTRA NOTES |
A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).[MeSH] |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE |
white to yellowish crystalline powder |
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MELTING POINT |
160 ~ 161 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
9500 mg/l |
| SOLVENT SOLUBILITY |
Soluble in diluted acids, DMF. |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
3.05E-07 mm Hg |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
(n20/D) |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Metronidazole Wikipedia Linking - Metronidazole Google Scholar Search - Metronidazole U.S. National Library of Medicine - Metronidazole PubChem Compound Summary - Metronidazole IPCS INCHEM - Metronidazole Drug Bank - Metronidazole KEGG (Kyoto Encyclopedia of Genes and Genomes) - Metronidazole ChEBI (http://www.ebi.ac.uk/chebi/) - Metronidazole NCBI (http://www.ncbi.nlm.nih.gov/) - Metronidazole Material Safety Data Sheet - Metronidazole Human Metabolome Database - Metronidazole Hazardous Substances Data Bank - Metronidazole EPA - Substance Registry Services - Metronidazole |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to yellowish crystalline powder |
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ASSAY |
99.0 ~ 101.0% |
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MELTING POINT |
159 ~ 163 C |
| RESIDUE ON IGNITION |
0.1% max |
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LOSS ON DRYING |
0.5% max |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Carcinogenicity. Hazard statements: May be harmful if swallowed. Suspected of causing cancer. |
| SIGNAL WORD | Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H303-H351 |
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P STATEMENTS |
P281 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
40 |
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SAFETY PHRASES |
36/37 |
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| PACKING |
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Preserved in light-resistant and well-closed bottles |
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| PRICE INFORMATION |
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