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MIMOSINE |
| Synonyms. Mimosine; (L)-Mimosine; (S)-alpha-Amino-3-hydroxy-4-oxo-1(4H)-pyridylpropionic acid; Leucenol; (2S)-2-Amino-3-(3-hydroxy-4-oxopyridin-1-yl)propanoic acid; beta-[N-(3-Hydroxy-4-pyridone)]-alpha-aminopropionic acid; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
500-44-7 |
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EINECS RN |
207-905-1 |
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FORMULA |
C8H10N2O4 |
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MOLE WEIGHT |
198.18 |
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H.S CODE |
2933.39.6190 |
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SMILES |
c1(c(=O)ccn(c1)C[C@H](N)C(=O)O)O |
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CLASSIFICATION |
Alkaloid |
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EXTRA NOTES |
3-Hydroxy-4-oxo-1(4H)-pyridinealanine. An antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca MeSH |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
228 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
-4.72 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Mimosine Wikipedia Linking - Mimosine Google Scholar Search - Mimosine U.S. National Library of Medicine - Mimosine PubChem Compound Summary - Mimosine Drug Bank - Mimosine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Mimosine ChEBI (http://www.ebi.ac.uk/chebi/) - Mimosine NCBI (http://www.ncbi.nlm.nih.gov/) - Mimosine Hazardous Substances Data Bank - Mimosine EPA - Substance Registry Services - Mimosine Biochem/physiol Actions L-Mimosine is a plant amino acid and potential inhibitor of the cell cycle giving rise to growth arrest in G1-phase. An iron chelator that inhibits DNA replication in mammalian cells. Has been shown to have apoptotic activity in xenotransplanted human pancreatic cancer. L-Mimosine is also used as a hypoxia-mimetic agent to stabilize Hypoxia Inducible Factor 1 (HIF-1). L-Mimosine stabilizes HIF-1 through the inhibition of Prolyl Hydroxylases (PHDs) which target HIF-1 through degradation. The mechanism of inhibition is likely through the chelation of Fe2+ bound to the active site of PHD which is required for enzymatic activity. sigmaaldrich |
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| SALES SPECIFICATION (L-Form) | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
99% min |
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MELTING POINT |
223 ~ 225 C |
| OPTICAL ROTATION |
-19° ~ -21° |
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LOSS ON DRYING |
1% max |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
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| HAZARD CLASS |
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| PACKING GROUP | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Inhalation). Acute toxicity (Dermal). Hazard statements: Harmful if swallowed or in contact with skin. Harmful if inhaled. |
| SIGNAL WORD | Warning |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H302 + H312-H332 |
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P STATEMENTS |
P261-P264-P270-P271-P280-P301 + P312-P302 + P352-P304 + P340-P312-P322-P330-P363-P501 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
20/21/22 |
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SAFETY PHRASES |
22-36 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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