MINOCYCLINE

Synonyms. Minocycline; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a- tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; Borymycin; Minociclina; Minocyclinum; Minocyn; Tri-minocycline; 7-Dimethylamino-6-demethyl-6-deoxytetracycline;

MINOCYCLINE

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

10118-90-8 (parent), 13614-98-7 (HCl)

EINECS RN

237-099-7

FORMULA

C23H27N3O7

MOLE WEIGHT

457.48

H.S CODE

 2941.30.0000

SMILES

 CN(C)c1ccc(c2c1C[C@H]3C[C@H]4[C@@H](C(=C(C(=O)[C@]4(C(= C3C2 =O)O )O)C(=O)N)O)N(C)C)O

CLASSIFICATION

Tetracycline antibiotic, Neuroprotective

EXTRA NOTES

A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant STAPHYLOCOCCUS infections. [MeSH]
Other RN: 17175-40-5, 24058-90-0, 146440-73-5, 1071761-03-9

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

yellow crystalline powder

MELTING POINT

205 ~ 210 C (Decomposes)

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

5.20E+04 mg/l

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

 0.05

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 2, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Minocycline

Wikipedia Linking - Minocycline

Google Scholar Search - Minocycline

U.S. National Library of Medicine - Minocycline

PubChem Compound Summary - Minocycline

Drug Bank -  Minocycline

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Minocycline

ChEBI (http://www.ebi.ac.uk/chebi/) -  Minocycline

NCBI (http://www.ncbi.nlm.nih.gov/) -  Minocycline

Hazardous Substances Data Bank - Minocycline

EPA - Substance Registry Services - Minocycline

http://www.sigmaaldrich.com/
Minocycline is a semi-synthetic tetracycline derivative that has a spectrum of antibacterial activity similar to tetracycline. It is active against streptococci, enterobacteria, and some mycobacteria, and also against such species as Staphylococcus aureus, Neisseria meningitidis, Acinetobacter, Bacteroides, Haemophilus, and Nocardia. Minimum inhibitory concentrations (MIC) can range from 0.06 - 1 μg/ml for the most sensitive organisms, and from 4 - 12.5 μg/ml for moderately sensitive organisms. A detailed review of minocycline has been published.

 

SALES SPECIFICATION

APPEARANCE

yellow crystalline powder

ASSAY

98.5% ~ 101.0%

RESIDUE ON IGNITION

0.15% max

CHLORIDE

0.015% max

SULFATE

0.02% max

LOSS ON DRYING

0.5% max

FREE SALICYLIC ACID

0.1% max

HEAVY METALS

10ppm max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Hazard statements: Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

SIGNAL WORD Warning

PICTOGRAMS

PICTOGRAM_GHS07_exclamation.jpg

HAZARD STATEMENTS

H303-H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

CODE_Xn_Xi_harmful_Irritant.gif

RISK PHRASES

36/37/38

SAFETY PHRASES

26-36

 

PACKING

Preserved in light-resistant and well-closed bottles

 

PRICE INFORMATION