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PICROTOXIN |
| Synonyms. Picrotoxin; Cocculus; Picrotin, compound with picrotoxinin; (1aR-(1aalpha, 2abeta,3beta, 6beta,6abeta,8aS*,8bbeta,9S*))-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)- 8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta (ij)cycloprop(a)azulene-4,8(3H)- dione compd with (1aR-(1aalpha,2abeta,3beta,6beta,6abeta,8aS*,8bbeta,9R*))- Hexahydro-2a- hydroxy-8b- methyl-9-(1-methylethenyl)- 3,6-methano-8H-1,5,7-trioxacyclopenta(ij)cycloprop(a)azulene- 4,8(3H)-dione; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
124-87-8 |
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EINECS RN |
204-716-6 |
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FORMULA |
C30H34O13 |
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MOLE WEIGHT |
602.58 |
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H.S CODE |
3002.90.5150 |
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SMILES |
O1[C@H]2[C@@]31[C@@]1([C@@](C2)([C@@H]2[C@H](C(C)(C)O)[C@ @H] ([C@H] 1OC3=O) OC2=O)O) C.O1[C@@]23[C@@] 4([C@@]([C@@ H]5[C@ H](C(C)=C)[C@@H]([C@H ]4OC3=O)OC5= O)(O)C[C@@H] 12)C |
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CLASSIFICATION |
GABA antagonist |
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EXTRA NOTES |
A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the gamma-aminobutyric acid-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates. [PubChem] |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE |
white to yellow powder |
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MELTING POINT |
203 ~ 204 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
4100 mg/l |
| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
-2.81 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 1, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Picrotoxin Wikipedia Linking - Picrotoxin Google Scholar Search - Picrotoxin U.S. National Library of Medicine - Picrotoxin PubChem Compound Summary - Picrotoxin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Picrotoxin NCBI (http://www.ncbi.nlm.nih.gov/) - Picrotoxin Material Safety Data Sheet - Picrotoxin Human Metabolome Database - Picrotoxin EPA - Substance Registry Services - Picrotoxin |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to yellow powder |
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ASSAY |
98% min |
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MELTING POINT |
203 ~ 205 C |
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LOSS ON DRYING |
1% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
3462 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | II |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Hazard statements: Fatal if swallowed. |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H300 |
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P STATEMENTS |
P264-P301 + P310 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
28 |
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SAFETY PHRASES |
28-36/37-45 |
T+|
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| PACKING |
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Preserved in light-resistant and well-closed bottles |
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