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PILOCARPINE |
| Synonyms. Pilocarpine; (3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone; (3S-cis)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone; alpha-Ethyl-beta-(hydroxymethyl)-1-methyl-imidazole-5-butyric acid gamma-lactone; Pilocarpol; Pilokarpin; Pilokarpol; Syncarpine; cis-3-Ethyl-4-(1-methyl-5-imidazolylmethyl)dihydro-2(3H)-furanone; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
92-13-7 (free base) |
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EINECS RN |
202-128-4 (free base) |
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FORMULA |
C11H16N2O2 |
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MOLE WEIGHT |
208.26 |
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H.S CODE |
2939.99.0000 |
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SMILES |
[C@H]1([C@@H](C(=O)OC1)CC)Cc1n(cnc1)C |
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CLASSIFICATION |
Tetrahydrofuran, Lactone, Alkaloid |
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EXTRA NOTES |
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma. MeSH |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white semi solid |
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MELTING POINT |
34 C |
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BOILING POINT |
260 C |
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DENSITY |
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SOLUBILITY IN WATER |
Soluble |
| SOLVENT SOLUBILITY |
Soluble in alcohol, chloroform, sparingly soluble in ether, benzene. |
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VAPOR DENSITY |
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log P(octanol-water) |
0.12 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
6.78 |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 4, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Pilocarpine Wikipedia Linking - Pilocarpine Google Scholar Search - Pilocarpine U.S. National Library of Medicine - Pilocarpine PubChem Compound Summary - Pilocarpine Drug Bank - Pilocarpine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Pilocarpine ChEBI (http://www.ebi.ac.uk/chebi/) - Pilocarpine NCBI (http://www.ncbi.nlm.nih.gov/) - Pilocarpine Hazardous Substances Data Bank - Pilocarpine EPA - Substance Registry Services - Pilocarpine |
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| SALES SPECIFICATION (HCl) | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% ~ 102% |
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MELTING POINT |
202 ~ 205 C |
| OPTICAL ROTATION |
+90° ~ +92° (c=2) |
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LOSS ON DRYING |
3% max |
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RELATED COMPOUNDS |
pass |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
1544 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | III |
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| SAFETY INFORMATION (HCl) | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Acute toxicity (Inhalation). Hazard statements: Fatal if swallowed or if inhaled. |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H315-H319-H335 |
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P STATEMENTS |
P261-P305 + P351 + P338 P261-P264-P270-P271-P280-P301 + P312-P302 + P352-P304 + P340-P312-P322-P330-P363-P501 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
26/28 |
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SAFETY PHRASES |
25-45 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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