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PIPERLONGUMINE |
| Synonyms. Piperlongumine; 1-[(E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]-2,3-dihydropyridin-6-one; (E)-5,6-Dihydro-1-(1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl)-2(1H)-pyridinone; 5,6-Dihydro-1-(1-oxo-3-[3,4,5-trimethoxyphenyl]-trans-2-propenyl)-2[1H]-pyridinone; 5,6-Dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-2(1H)-pyridinone; Piplartin; Piplartine; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
20069-09-4 |
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EINECS RN |
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FORMULA |
C17H19NO5 |
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MOLE WEIGHT |
317.34 |
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H.S CODE |
2933.39.6190 |
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SMILES |
COc1cc(cc(c1OC)OC)\C=C\C(=O)N1CCC=CC1=O |
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CLASSIFICATION |
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EXTRA NOTES |
Biochem/physiol Actions Piperlongumine selectively kills cancer cells regardless of p53 status without harming normal cells. It binds to and inihbits proteins known to regulate oxidative stress, in particular, Glutathione S-transferase pi 1 (GSTP1). It increases the level of reactive oxygen species (ROS) and apoptotic cell death in cancer cells with little effect on either rapidly or slowly dividing primary normal cells. Piperlongumine showed significant antitumour effects in a variety of mouse tumour models and inhibited growth of spontaneously formed malignant breast tumours and their associated metastases. sigmaaldrich |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 1, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Piperlongumine Wikipedia Linking - Piperlongumine Google Scholar Search - Piperlongumine U.S. National Library of Medicine - Piperlongumine PubChem Compound Summary - Piperlongumine Drug Bank - Piperlongumine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Piperlongumine ChEMBL (http://www.ebi.ac.uk/) - Piperlongumine NCBI (http://www.ncbi.nlm.nih.gov/) - Piperlongumine |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to yellow powder |
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ASSAY |
98% min |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Not a dangerous substance. |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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