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PLUMBAGIN |
| Synonyms. Plumbagin; 2-Methyl-5-hydroxy-1,4-naphthoquinone; 2-Methyljuglone; 5-Hydroxy-2-methyl-1,4-naphthalenedione; 5-Hydroxy-2-methyl-1,4-naphthoquinone; Plumbaein; Plumbagine; Plumbagone; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
481-42-5 |
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EINECS RN |
207-569-6 |
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FORMULA |
C11H8O3 |
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MOLE WEIGHT |
188.18 |
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H.S CODE |
2914.69.6000 |
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SMILES |
c12c(C(C=C(C1=O)C)=O)c(ccc2)O |
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CLASSIFICATION |
Anti-proliferative agent, Naphthoquinone |
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EXTRA NOTES |
Plumbagin exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma. Plumbagin is a unique suppressor of CXCR4 expression making in useful in studies of cancer metastasis. Plumbagin has antifungal, antiviral, and antibacterial action. sigmaaldrich |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE |
white to off-white crystalline powder |
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MELTING POINT |
78 ~ 79 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
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| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
2.5 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents. |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 3, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Plumbagin Wikipedia Linking - Plumbagin Google Scholar Search - Plumbagin U.S. National Library of Medicine - Plumbagin PubChem Compound Summary - Plumbagin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Plumbagin ChEBI (http://www.ebi.ac.uk/chebi/) - Plumbagin NCBI (http://www.ncbi.nlm.nih.gov/) - Plumbagin Material Safety Data Sheet - Plumbagin Human Metabolome Database - Plumbagin EPA - Substance Registry Services - Plumbagin |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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MELTING POINT |
76 ~ 78 C |
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LOSS ON DRYING |
1% max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
2923 |
| HAZARD CLASS |
8 |
| PACKING GROUP | II |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral).Skin corrosion. Serious eye damage. Hazard statements: Toxic if swallowed. Causes severe skin burns and eye damage. |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H301-H314 |
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P STATEMENTS |
P280-P305 + P351 + P338-P310 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
26-34 |
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SAFETY PHRASES |
22-26-36/37/39-45 |
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| PACKING |
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Preserved in light-resistant and well-closed bottles |
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