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PODOFILOX |
| Synonyms. Podofilox; Podophyllotoxin; (5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy -5-(3,4,5-trimethoxyphenyl)furo(3',4':6,7)naphtho(2,3-d)- 1,3-dioxol-6(5aH)-one; Condyline; Condylox; Podophyllinic acid lactone; Podophyllotoxin; (5R,5aR,8aR,9R)-5-Hydroxy-9-(3,4,5-trimethoxyphenyl)- 5a,6,8a,9- tetrahydro-5H-[2]benzofuro [5,6-f][1,3]benzodioxol-8-one; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
518-28-5 |
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EINECS RN |
208-250-4 |
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FORMULA |
C22H22O8 |
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MOLE WEIGHT |
414.41 |
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H.S CODE |
3002.90.5150 |
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SMILES |
[C@H]1(c2c([C@@H]([C@@H]3[C@@H]1C(=O)OC3)O)cc1c (c2)OCO1)c 1cc (c (c(c1)OC)OC)OC |
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CLASSIFICATION |
Antitumor agent |
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EXTRA NOTES |
A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives. MeSH |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
183 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
155 mg/l |
| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 3, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Podofilox Wikipedia Linking - Podophyllotoxin Google Scholar Search - Podofilox U.S. National Library of Medicine - Podofilox PubChem Compound Summary - Podophyllotoxin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Podofilox ChEBI (http://www.ebi.ac.uk/chebi/) - Podofilox NCBI (http://www.ncbi.nlm.nih.gov/) - Podofilox Material Safety Data Sheet - Podofilox Hazardous Substances Data Bank - Podofilox |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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MELTING POINT |
182 ~ 183 C |
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LOSS ON DRYING |
1% max |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
3462 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | II |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Dermal). Acute toxicity (Oral). Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Hazard statements: Toxic if swallowed. Fatal in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H301-H310-H315-H319-H335 |
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P STATEMENTS |
P261-P280-P302 + P350-P305 + P351 + P338-P310 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
21-25-36/37/38 |
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SAFETY PHRASES |
36/37/39-45 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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