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PROTOPINE |
| Synonyms. Protopine; 4,6,7,14-Tetrahydro-5-methyl-bis(1,3)benzodioxolo(4,5-c-5',6'-g)azecin-13(5H)-one; 7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one; Biflorine; 4,6,7,14-Tetrahydro-5-methyl-bis(1,3)benzodioxolo(4,5-c:5',6'-g)azecin-13(5H)-one; Corydinine; Fumarine; Macleyine; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
130-86-9 (free base) |
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EINECS RN |
204-999-6 (free base) |
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FORMULA |
C20H19NO5 |
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MOLE WEIGHT |
353.37 |
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H.S CODE |
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SMILES |
CN1CCC2=CC3=C(C=C2C(=O)CC4=C(C1)C5=C(C=C4)OCO5)OCO3 |
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CLASSIFICATION |
Alkaloid |
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EXTRA NOTES |
Protopine is a benzylisoquinoline alkaloid occurring in opium poppy, Corydalis tubers and other plants of the family papaveraceae, like Fumaria officinalis. It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic wikipedia |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystal |
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MELTING POINT |
208 C |
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BOILING POINT |
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DENSITY |
1.399 |
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SOLUBILITY IN WATER |
Insoluble |
| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
3.47 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Protopine Wikipedia Linking - Protopine Google Scholar Search - Protopine U.S. National Library of Medicine - Protopine PubChem Compound Summary - Protopine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Protopine ChEBI (http://www.ebi.ac.uk/chebi/) - Protopine NCBI (http://www.ncbi.nlm.nih.gov/) - Protopine Hazardous Substances Data Bank - Protopine |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystal |
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ASSAY |
98% min |
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MELTING POINT |
208 C |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
2811 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | III |
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| SAFETY INFORMATION (HCl) | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Hazard statements: Toxic if swallowed. |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H301 |
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P STATEMENTS |
P301 + P310 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
25 |
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SAFETY PHRASES |
36/37/39-45 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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