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QUINIDINE |
| Synonyms. Quinidine; (8R,9S)-6'-Methoxycinchonan-9-ol; (+)-Quinidine; (8R,9S)-Quinidine; (9S)-6'-Methoxycinchonan-9-ol; (9S)-6-Methoxy-alpha-(5-vinyl-2-quinuclidinyl)-4-quinolinemethanol; (9S)-alpha-(6-Methoxy-4-quinolyl)-5-vinyl-2-quinuclidinemethanol; beta-Quinine; Chinidin; Conchinin; Conquinine; Pitayine; Quinidex; |
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| PRODUCT IDENTIFICATION | |
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CAS RN |
56-54-2 (free base) |
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EINECS RN |
200-279-0 (free base) |
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FORMULA |
C20H24N2O2 |
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MOLE WEIGHT |
324.42 |
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H.S CODE |
2939.20.0010 |
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SMILES |
c12c([C@@H]([C@@H]3N4C[C@@H](C(C3)CC4)C=C)O)ccnc1ccc(c2) OC |
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CLASSIFICATION |
Antiarrhythmic agent, Quinoline |
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EXTRA NOTES |
An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission. MeSH |
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| PHYSICAL AND CHEMICAL PROPERTIES | |
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PHYSICAL STATE. |
white to off-white crystalline powder |
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MELTING POINT |
174 C |
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BOILING POINT |
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DENSITY |
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SOLUBILITY IN WATER |
140 mg/l |
| SOLVENT SOLUBILITY |
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VAPOR DENSITY |
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log P(octanol-water) |
3.44 |
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VAPOR PRESSURE |
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AUTOIGNITION TEMP |
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| pK |
8.56 |
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REFRACTIVE INDEX |
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FLASH POINT |
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| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
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INCOMPATIBLE MATERIALS |
Strong oxidizing agents |
| POLYMERIZATION |
Has not been reported |
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NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
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| EXTERNAL LINKS & GENERAL DESCRIPTION |
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USA.gov - Quinidine Wikipedia Linking - Quinidine Google Scholar Search - Quinidine U.S. National Library of Medicine - Quinidine PubChem Compound Summary - Quinidine Drug Bank - Quinidine KEGG (Kyoto Encyclopedia of Genes and Genomes) - Quinidine ChEBI (http://www.ebi.ac.uk/chebi/) - Quinidine NCBI (http://www.ncbi.nlm.nih.gov/) - Quinidine |
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| SALES SPECIFICATION | |
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APPEARANCE |
white to off-white crystalline powder |
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ASSAY |
98% min |
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MELTING POINT |
168 ~ 172 C |
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RELATED SUBSTANCE |
20% max (Dihydroquinidine) |
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HEAVY METALS |
10ppm max |
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| TRANSPORT & REGULATORY INFORMATION | |
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UN NO. |
2811 |
| HAZARD CLASS |
6.1 |
| PACKING GROUP | III |
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| SAFETY INFORMATION | |
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HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Skin irritation. Hazard statements: Toxic if swallowed. Causes mild skin irritation. |
| SIGNAL WORD | Danger |
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PICTOGRAMS |
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HAZARD STATEMENTS |
H301 |
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P STATEMENTS |
P301-P316 |
| EC DIRECTIVES |
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| HAZARD CODES |
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RISK PHRASES |
22 |
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SAFETY PHRASES |
36 |
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| PACKING |
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Preserve in light-resistant and well-closed containers |
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