|
SILIBININ |
| Synonyms. Silibinin; 3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl)- 4-chromanone; Flavobin; Silibinina; Silibinine; Silibininum; Silliver; Silybine; Silymarin I; Silymarine I; 2,3-Dihydro-3-(4-hydroxy-3-methoxyphenyl)-2- (hydroxymethyl)-6-(3,5,7-trihydroxy-4- oxobenzopyran-2-yl)benzodioxin; |
|
|
| PRODUCT IDENTIFICATION | |
|
CAS RN |
22888-70-6 |
|
EINECS RN |
245-302-5 |
|
FORMULA |
C25H22O10 |
|
MOLE WEIGHT |
482.44 |
|
H.S CODE |
2932.99.6100 |
|
SMILES |
c1([C@@H]2[C@H](Oc3ccc(cc3O2)[C@H]2Oc3c(c(cc(c3)O)O)C ([C@@H] 2O)= O)CO)cc(c(O) cc1)OC |
|
CLASSIFICATION |
Antidote, Flavonolignan |
|
EXTRA NOTES |
The major component of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; has antineoplastic activity. |
|
|
| PHYSICAL AND CHEMICAL PROPERTIES | |
|
PHYSICAL STATE. |
white to off-white crystalline powder |
|
MELTING POINT |
167 C |
|
BOILING POINT |
|
|
DENSITY |
|
|
SOLUBILITY IN WATER |
Insoluble |
| SOLVENT SOLUBILITY |
Soluble in acetone, ethyl acetate, methanol, ethanol. Sparingly soluble in CHCl3. |
|
VAPOR DENSITY |
|
|
log P(octanol-water) |
|
|
VAPOR PRESSURE |
|
|
AUTOIGNITION TEMP |
|
| pK |
|
|
REFRACTIVE INDEX |
|
|
FLASH POINT |
|
|
|
| STABILITY AND REACTIVITY | |
| STABILITY | Stable under normal conditions. |
|
INCOMPATIBLE MATERIALS |
Strong oxidizing agents, Strong bases. |
| POLYMERIZATION |
Has not been reported |
|
NFPA RATINGS |
Health: 2, Flammability: 0, Reactivity: 0 |
|
|
| EXTERNAL LINKS & GENERAL DESCRIPTION |
|
USA.gov - Silibinin Wikipedia Linking - Silibinin Google Scholar Search - Silibinin U.S. National Library of Medicine - Silibinin PubChem Compound Summary - Silibinin KEGG (Kyoto Encyclopedia of Genes and Genomes) - Silibinin ChEBI (http://www.ebi.ac.uk/chebi/) - Silibinin NCBI (http://www.ncbi.nlm.nih.gov/) - Silibinin |
|
|
| SALES SPECIFICATION | |
|
APPEARANCE |
white to off-white crystalline powder |
|
ASSAY |
98% min |
|
MELTING POINT |
165 ~ 167 C |
| OPTICAL ROTATION |
+10° ~ +12° (c=0.25, acetone) |
|
LOSS ON DRYING |
1% max |
|
HEAVY METALS |
10ppm max |
|
|
| TRANSPORT & REGULATORY INFORMATION | |
|
UN NO. |
|
| HAZARD CLASS |
|
| PACKING GROUP | |
|
|
| SAFETY INFORMATION | |
|
HAZARD OVERVIEW |
GHS (Globally Harmonised System) Classification: Acute toxicity (Oral). Skin irritation. Eye irritation. Specific target organ toxicity - single exposure. Hazard statements: Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. |
| SIGNAL WORD | Warning |
|
PICTOGRAMS |
|
|
HAZARD STATEMENTS |
H315-H319-H335 |
|
P STATEMENTS |
P261-P305 + P351 + P338 |
| EC DIRECTIVES |
|
| HAZARD CODES |
|
|
RISK PHRASES |
36/37/38 |
|
SAFETY PHRASES |
26-37/39 |
|
|
| PACKING |
|
Preserve in light-resistant and well-closed containers |
|
|