p-HYDROXYBUTYROPHENONE

PRODUCT IDENTIFICATION
CAS NO. 1009-11-6

p-HYDROXYBUTYROPHENONE
EINECS NO. 213-766-8
FORMULA C10H12O2
MOL WT. 164.21

H.S. CODE

  
TOXICITY  
SYNONYMS 4-Butyrylphenol; 4-Hydroxybutyrophenone; p-Butyrylphenol;
p-Hydroxyphenyl propyl ketone; 1-(4-Hydroxyphenyl)-1-butanone;
DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE white crystal
MELTING POINT 91 - 93 C
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

  
FLASH POINT  
STABILITY stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Propiophenone (Phenyl ethyl ketone) is a useful intermediate to prepare nervous system drugs (anxiolytic and hypnotic drugs). Bupropion is an example which has propiophenone moiety. Bupropion is an aminoketone class antidepressant. Propiophenone is used in the synthesis of  ketoamphetamines such as cathinone and methcathinone. Propiophenone can also be converted to synthetic aryl alkenes such as cinnamic acids. Propiophenone is a constituent of synthetic perfumes, flavouring agents, and of paints to stabilize other ingredients. Ketones can be made by the oxidation of secondary alcohols and the destructive distillation of certain salts of organic acids. In addition to as polar solvents, ketones are important intermediates in the syntheses of organic compounds such as alkoxides, hydroxyalkynes, imines, alcohols (primary, secondary as well as tertiary), acetals, thioacetals, phosphine oxides, geminal diols, hydrazones, organic sulfite and cyanohydrins. Propiophenone is a clear liquid that is insoluble in water, but miscible with methanol, ethanol, diethyl ether, benzene and toluene.

Butyrophenone is the basic structure of antipsychotic drugs such as droperidol, azaperone, trifluperidol, bromperidol, and haloperidol. Chemical structure of Neuroleptic agents are diverse; including phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines, dihydroindolones, and diphenylbutylpiperidines. Some vermicides have hydroxy or methoxy butyrophenone (Desaspidin).

Members of aryl ketone

Systemic name

Common name

CAS RN

Phenyl ethyl ketone

 Propiophenone 93-55-0

Phenyl styryl ketone

 Chalcone 94-41-7

Phenyl methyl ketone

 Acetophenone 98-86-2
Diphenyl ketone Benzophenone 119-61-9
Phenyl phenacyl ketone Dibenzoylmethane 120-46-7

Phenyl o-tolyl ketone

 2-Methylbenzophenone 131-58-8

Phenyl p-tolyl ketone

 4-Methyl benzophenone 134-84-9
Phenyl 2-thienyl ketone Phenyl-2-thienylmethanone 135-00-2
Phenyl benzyl ketone Deoxybenzoin 451-40-1
Phenyl 1-propenyl ketone Crotonophenone 495-41-0
Phenyl propyl ketone Butyrophenone 495-40-9
Phenyl methyl diketone 1-Phenyl-1,2-propanedione 579-07-7

Phenyl trans-styryl ketone

 trans-Chalcone 614-47-1

Phenyl vinyl ketone

 2-Propenophenone 768-03-6
Phenyl phenethyl ketone Dihydrochalcone 1083-30-3

Phenyl xylyl ketone

 

 1322-78-7

Phenyl ethynyl ketone

 Propynophenone 3623-15-2
SALES SPECIFICATION

APPEARANCE

white crystal

ASSAY

99.0% min
MELTING POINT 91 - 93 C

MOISTURE

0.5% max

TRANSPORTATION
PACKING  
HAZARD CLASS  
UN NO.  
OTHER INFORMATION