2,6-DIISOPROPYLPHENOL

PRODUCT IDENTIFICATION
CAS NO. 2078-54-8

2,6-DIISOPROPYLPHENOL
EINECS NO. 218-206-6
FORMULA [(CH3)2CH]2C6H3OH
MOL WT. 178.27
H.S. CODE 2907.19

TOXICITY

 Oral rat LD50: 500 mg/kg
SYNONYMS Propofol; Diprivan; Diisopropylphenol;
2,6-Bis(1-methylethyl)Phenol; Disoprofol;

SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE clear to pale yellow liquid
MELTING POINT 18 C
BOILING POINT

256 C
SPECIFIC GRAVITY 0.962
SOLUBILITY IN WATER

 
pH

 
VAPOR DENSITY  

AUTOIGNITION

 

NFPA RATINGS

 
REFRACTIVE INDEX

1.512 - 1.516 at 20C
FLASH POINT

112 C
STABILITY

Stable under ordinary conditions

APPLICATIONS
Propofol is a non-barbiturate sedative to induce anesthesia sedation only, or general anesthesia for procedures lasting less than one hour. It is known as an intravenous anesthetic agent which has the advantage of rapid loss of consciousness after infusion or bolus injection plus a very short recovery period of a couple of minutes. Its pharmacologic actions also include anticonvulsant, antiemetic, hypnotic and sedative and free radical scavenging. Propofol is a clear to pale yellow liquid; very slightly soluble in water; administered intravenously in a form of oil-in-water emulsion. It is also used as a raw materials of sedative, hypnotic, and anesthetic.

Members of Intravenous Anesthetic

Product

CAS RN
Urethane 51-79-6
Thiopental sodium 71-73-8
Thiopental 76-75-5
Thiamylal 77-27-0
Methohexital 151-83-7
Chloral hydrate 302-17-0
Methohexital sodium 309-36-4
Thiamylal sodium 337-47-3
Fentanyl 437-38-7
Diazepam 439-14-5
Sodium oxybate 502-85-2
Propanidid 1421-14-3
Propofol 2078-54-8
Chloralose 15879-93-3
Etomidate 33125-97-2
Sufentanil 56030-54-7
Midazolam 59467-70-8
Midazolam maleate 59467-94-6
Alfentanil 71195-58-9
Remifentanil 132875-61-7
SALES SPECIFICATION

APPEARANCE

clear to pale yellow liquid
ASSAY 98.0 - 102.0% (titration)

WATER

0.2% max

CHLORIDE

300ppm max

IMPURITY

0.3% max (total impurity)
0.2% max (individual impurity)

SOLVENT RESIDUE

0.1% max
REFRACTIVE INDEX

1.512 - 1.516 at 20C
TRANSPORTATION
PACKING 5kgs in can, 180kgs in Drum
HAZARD CLASS 8
UN NO. 3145 (Packing Group: III)
OTHER INFORMATION
Hazard Symbols: XN, Risk Phrases: 22, Safety Phrases: 24/25