PICOLINES

GENERAL

alpha-PICOLINE, beta-PICOLINE, and gamma-PICOLINE. The three compounds are structural isomers. The names of the three compounds indicate which of the hydrogens on the benzene ring portion of the molecule have been replaced. They are obtained from coal tar or petroleum. Because the boiling points of these three compounds are nearly the same, a separation of a mixture of the three into its pure components is impractical. PICOLINES are useful as solvents and as raw materials for various chemical products used in the industry of polymers, textiles, fuels, agrochemicals, pharmaceuticals and colorants.

alpha-PICOLINE

beta-PICOLINE

gamma-PICOLINE

alpha-PICOLINE

beta-PICOLINE

gamma-PICOLINE

CAS No. : 109-06-8
2-Methylpyridine

CAS No. : 108-99-6
3
-Methylpyridine

CAS No. : 108-89-4
4
-Methylpyridine

APPLICATION

Solvents, Raw materials for various chemical products used in the industry of polymers, textiles, fuels, agrochemicals, pharmaceuticals and colorants.

PHYSICAL PROPERTY

PROPERTY

a-PICOLINE

b-PICOLINE

g-PICOLINE

Melting Point

66.5 - 67.5 C

18.0 - 19.0 C

3.0 - 4.0 C

Boiling point (at 760mmHg)

129 - 130 C

143 - 144 C

144.5 - 145.5 C

Specific Gravity (at 25C)

0.9393

0.952

0.9504

Refractive Index nD25

1.4990 - 1.5000

1.5000 - 1.5010

1.5030 - 1.5040

SPECIFICATION

PROPERTY

a-PICOLINE

b-PICOLINE

g-PICOLINE

Appearance

Clear Liquid to Pale Yellow Liquid

Purity (by GC)

99.0% min

98.0% min

98.0% min

Moisture

0.15% max

0.2% max

0.2% max

Color (Pt-Co Scale)

25

25

-

SYNONYMS

alpha-PICOLINE
2-Methylpyridine, Alpha-methylpyridine, 2-Picoline
beta-PICOLINE
3-Picoline, 3-Methylpyridine, beta-methylpyridine
gamma-PICOLINE
4-Picoline, sigma-Picoline, G-Picoline, 4-Methylpyridine 

COMMENTS

Packing : 190kgs in Drum
GENERAL DESCRIPTION OF PYRIDINE
PYRIDINE, also called azabenzene and azine, is a heterocyclic aromatic tertiary amine characterized by a six-membered ring structure composed of five carbon atoms and a nitrogen which replace one carbon-hydrogen unit in the benzene ring (C5H5N). The simplest member of the pyridine family is pyridine itself. It is colorless, flammable, toxic liquid with a unpleasant odor, miscible with water and with most organic solvents, boils at 115 C. Its aqueous solution is slightly alkaline. Its conjugate acid is called pyridinium cation, C5H5NH+, used as a oxidation agent for organic synthesis.. Pyridine is a base with chemical properties similar to tertiary amines. Nitrogen in the ring system has an equatorial lone pair of electrons, that does not participate in the aromatic pi-bond. Its aqueous solution is slightly alkaline. It is incompatible and reactive with strong oxidizers and strong acids, and reacts violently with chlorosulfonic acid, maleic anhydride, oleum, perchromates, b-propiolactone, formamide, chromium trioxide, and sulfuric acid. Liquid pyridine easily evaporates into the air. If it is released to the air, it may take several months to years until it breaks down into other compounds. Usually, pyridine is derived from coal tar or synthesized from other chemicals, mainly acetaldehyde and ammonia. Pyridine compounds are found in nature. For example, nicotine from tobacco, ricinine from castor bean, pyridoxine or vitamin B and P products, alkaloids (such as coniine, piperine and nicotine), and etc. Some pyridine compounds consumed largely are;

Picoline : Three structural isomers of methyl pyridines (alpha, beta, gamma- positions)
Lutidine : Six structural isomers of dimethyl pyridines (2,3-, ,24-, 2,5-, 2,6-, 3,4-, 3,5- positions)
Collidine : Three structural isomers of trimethyl pyridines (2,3,5-, 2,3,6-, 2,4,6- positions)
Pyrimidine: Pyridine alteration containing nitrogen atoms at positions 1 and 3
Piperidine: Hexahydropyridine (saturated form)
Nicotinic acid: pyridine-3-carboxylic acid

Pyridine and its derivatives are very important in industrial field as well as in bio chemistry. Nucleotide consist of either a nitrogenous heterocyclic base (purine or pyrimidine). Three major pyrimidines in living systems are cytosine, thymine, and uracil. Pyrimidine and its derivatives are biologically important components of nucleic acids (DNA, RNA) and coenzymes. Some pyridine system is active in the metabolism in the body. They can be the parent compound of many drugs, including the barbiturates. Pyridine and its derivatives are used as solvents and starting material for the synthesis of target compounds such as insecticides, herbicides, medicines, vitamins, food flavorings, feed additives, dyes, rubber chemicals, explosives, disinfectants, and adhesives. Pyridine is also used as a denaturant for antifreeze mixtures, as a dyeing assistant in textiles and in fungicides. Compounds not made from pyridine but containing its ring structure include niacin and pyridoxal; isoniazid, nicotine, and several other nitrogenous plant products.

PICOLINE PRODUCTS

Product

CAS RN

1-(2'-Hydroxyphenylacetyl)-4-methyl-1,2,3,6-tetrahydropyridine 24789-84-2
1,4-Dihydro-4-imino-1-phenethyl-2-picoline monohydrobromide 33262-96-3
1-Phenethyl-2-picolinium bromide 10551-21-0
2-(2-Chloroethyl)-6-methylpyridine hydrochloride 17944-62-6
2-(3,4,5-Trimethoxybenzamido)-3-picoline 36845-03-1
2-(o-Aminobenzamido)-3-picoline 36844-99-2
2-(p-(Dimethylamino)benzamido)-3-picoline 36844-94-7
2-(p-Aminobenzamido)-3-picoline dihydrochloride 17710-07-5
2-(p-Aminobenzamido)-3-picoline 17710-06-4
2-(p-Aminobenzamido)-4-picoline 36845-05-3
2-(p-Amino-N-methylbenzamido)-3-picoline 36844-96-9
2-(p-Chlorobenzamido)-3-picoline 36845-02-0
2-(p-Methylbenzamido)-3-picoline 36845-01-9
2-(p-Nitrobenzamido)-3-picoline 17710-04-2
2,2'-Bipyridine, 4,4'-dimethyl- 1134-35-6
2-Amino-3-methylpyridine 1603-40-3
2-Amino-4-picoline 695-34-1
2-Amino-6-picoline 1824-81-3
2-Benzamido-3-picoline 23612-46-6
2-Formylpyridine thiosemicarbazone 3608-75-1
2-Methyl-5-ethylpyridine 104-90-5
2-Methyl-5-vinylpyridine 140-76-1
2-Methylpiperidine 109-05-7
2-Methylpyridine 109-06-8
2-Methylpyridine-1-oxide-4-azo-p-dimethylaniline 7347-46-8
2-Methylpyridine-4-azo-p-dimethylaniline 41287-11-0
2-Picoline, 4-((p-(dimethylamino)phenyl)azo)- 63019-78-3
2-Picoline, 5-ethyl-, 1-oxide 768-44-5
2-Picoline-6-amino-4-nitro-1-oxide 40314-76-9
2-Picoline-N-oxide hydrochloride 19305-07-8
3-(2-Chloroethyl)-2-methylpyridine hydrochloride 5959-98-8
3-(Chloromethyl)pyridine 3099-31-8
3-Ethyl-2-picoline hydrochloride 31299-84-0
3-Ethyl-4-picoline 529-21-5
3-Methyl-4-aminopyridine 1990-90-5
3-Methyl-4-nitropyridine 1-oxide 1074-98-2
3-Methylpiperidine 626-56-2
3-Methylpyridine 108-99-6
3-Methylpyridine-1-oxide-4-azo-p-dimethylaniline 31932-35-1
3-Picoline-4-carboxaldehyde, thiosemicarbazone 3608-78-4
3-Picoline-N-oxide 1003-73-2
4-((4-(Dimethylamino)-m-tolyl)azo)-2-picoline 1-oxide 7347-47-9
4-((4-(Dimethylamino)-m-tolyl)azo)-3-picoline 1-oxide 19456-74-7
4-((4-(Dimethylamino)-o-tolyl)azo)-2-picoline 1-oxide 7347-48-0
4-((4-(Dimethylamino)-o-tolyl)azo)-3-picoline 1-oxide 19471-28-4
4-(alpha-(2-(Dimethylamino)ethyl)benzyl)-2-picoline 101602-45-3
4-(p-aminobenzamido)-3-picoline 36855-65-9
4-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)-2-picoline 101581-59-3
4-(p-Nitrobenzamido)-3-picoline 36855-64-8
4,6-Bis((3-chloro-3,3-difluoro-2-hydroxy-2-trifluoromethyl)propyl)-2-picoline 102206-52-0
4-Benzylpicoline 7300-29-0
4-Ethyl-2-picoline 536-88-9
4-Methyl-2-aminopyridine-palladium chloride 77839-67-9
4-Methyl-2-pyridinamine hydrochloride 32654-41-4
4-Methyl-N-(phenylmethyl)-2-pyridinamine 13021-71-1
4-Methylpyridine 108-89-4
4-Methylpyridine 108-89-4
4-Nitro-3-picoline 1678-53-1

4-Picoline-N-oxide

1003-67-4

5-(3-Piperidino-1-propynyl)-2-picoline 73771-10-5
5-Acetyl-2-picoline 36357-38-7
6-(p-aminobenzamido)-2-picoline 36845-08-6
6-(p-Aminobenzamido)-3-picoline 17710-08-6
6-(p-Nitrobenzamido)-2-picoline 37586-00-8
6,6'-Dimethyl-2,2'-bipyridyl 4411-80-7
6-Amino-beta-picoline 1603-41-4
6-Chloro-2-picoline 18368-63-3
6-Iodo-2-picolin-5-ol 23003-30-7
6-Methoxy-3-picoline 13472-56-5
6-Methylpyridine-2-carboxylic acid 934-60-1
Dichlorotetrakis(3-picoline)rhodium(1+) chloride 97348-99-7
Hexachloro-2-picoline 76840-11-4
Methylpyridine 1333-41-1
Picoline, 1-oxide (6CI,7CI) 51279-53-9
Poly(N-ethyl-N-(2-chloroethyl)-p-aminobenzaldehyde, gamma-picoline) 71566-74-0
Polychlorinated picoline 70024-85-0
Pyridine, 2,3,4,5-tetrachloro-6-(trichloromethyl)- 1134-04-9
Pyridine, 2-methyl-, 1-oxide 931-19-1
Pyridoxine 65-23-6
Pyridoxine hydrochloride 58-56-0
Pyridoxine tripalmitate 4372-46-7
Pyroxychlor 7159-34-4
S-2-((5-(4-Methyl-2-pyridyloxy)pentyl)amino)ethyl hydrogen thiosulfate 41287-10-9
trans-Dichlorotetrakis(3-picoline)rhodium chloride 22933-76-2