p-CHLOROTOLUENE

PRODUCT IDENTIFICATION

CAS NO. 106-43-4

p-CHLOROTOLUENE

EINECS NO. 203-397-0
FORMULA CH3C6H4Cl
MOL WT. 126.59
H.S. CODE  

TOXICITY

Oral rat LD50: 2100 mg/kg.
SYNONYMS 4-Chloro-1-Methylbenzene; 4-Methylchlorobenzene; PCT;
1-Chloro-4-Methylbenzene; 1-Methyl-4-chlorobenzene; p-tolyl chloride; 4-Chlorotoluene; 4-Clorotolueno (Spanish); 4-Chlortoluol (German);

SMILES

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE clear liquid
MELTING POINT 6 - 8 C
BOILING POINT

162 C

SPECIFIC GRAVITY 1.07
SOLUBILITY IN WATER Slightly soluble

SOLVENT SOLUBILITY

Soluble in alcohol, chloroform, benzene, and ether
pH  
VAPOR DENSITY 4.38
AUTOIGNITION

595 C

NFPA RATINGS Health: 1 Flammability: 1 Reactivity: 0

REFRACTIVE INDEX

1.519 - 1.521
FLASH POINT 49 C
STABILITY Stable under ordinary conditions

DESCRIPTION AND APPLICATIONS

When substituted benzene molecules undergo electrophilic substitution reactions, substituents on a benzene ring can influence the reactivity. Activating substituents that activate the benzene ring toward electrophilic attack can alter the reaction rate or products by electronically or sterically affecting the interaction of the two reactants. deactivating substituents removes electron density from the benzene ring, making electrophilic aromatic substitution reactions slower and more difficult than benzene itself. For example, a hydroxy or methoxy substituent in phenol and anisole increases the rate of electrophilic substitution, while a nitro substituent decreases the ring's reactivity. Electron donating substituents activate the benzene ring toward electrophilic attack, and electron withdrawing substituents deactivate the ring, making it less reactive to electrophilic attack. The strongest activating substituents are the amino (-NH2) and hydroxyl (-OH) groups.

Reactivity Effects

Activating substituents

Deactivating substituents

Strong

-NH2, -NHR, -NR2, -OH, -O-

-NO2, -NR3+, -CF3, CCl3

Moderate

-NHCOCH3, -NHCOR, -OCH3,-OR

-CN, -SO3H, -COOH, -COOR, -COH, -COR

Weak

-CH3, -C2H5, -R, -C6H5

-F, -Cl, -Br, -I

Toluene, aniline and phenol are activated aromatic compounds. Examples of deactivated aromatic compounds are nitrobenzene, benzaldehyde and halogenated benzenes.

Activating substituents generally direct substitution to the ortho and para positions where substitutions must take place. With some exceptions, deactivating substituents direct to the meta position. Deactivating substituents which orient ortho and para- positions are the halogens (-F, -Cl, -Br, -I) and -CH2Cl, and -CH=CHNO2

When disubstituted benzene molecules undergo electrophilic substitution reactions, a new substituent is directed depends on the orientation of the existing substituents and their individual effects; whether the groups have cooperative or antagonistic directing effects. Ortho position is the most reactive towards electrophile due to the highest electron density ortho positions. But this increased reactivity is countervailed by steric hindrance between substituent and electrophile.

A nucleophilic substitution is a substitution reaction which the nucleophile displaces a good leaving group, such as a halide on an aromatic ring. This mechanism is called SNAr ( the two-step addition-elimination mechanism), where electron withdrawing substituents activate the ring towards nucleophilic attack. Addition-elimination reactions usually occur at sp2 or sp hybridized carbon atoms, in contrast to SN1 and SN2 at sp3. Chloro and bromobenzene reacts with the very strong base sodium amide (NaNH2) to give good yields of aniline. Other nucleophilic aromatic substitution mechanisms include benzyne mechanism and free radical (SRN1) mechanism.

Common reactions of substituent groups on benzene ring include:
  • Conversion of halogens into other various substituents
  • Modifying activating substituents
  • Oxidative degradation of alkyl chain
  • Reduction of nitro or carbonyl substituents
  • Reversibility of the aromatic sulfonation reaction

p-Chlorotoluene is used as a solvent and as an intermediate for organic synthesis especially for dyes.

SALES SPECIFICATION

APPEARANCE

clear liquid

PURITY

99.0% max

ISOMER

1.0% max

COLOR, APHA

15 max

WATER

0.3% max

TRANSPORTATION
PACKING 200kgs in drum
HAZARD CLASS 3 (Packing Group: III)
UN NO. 2238
OTHER INFORMATION
Hazard Symbols: XN N, Risk Phrases: 10-20-51/53, Safety Phrases: 24/25-61