PRODUCT IDENTIFICATION
106-94-5
203-445-0
TOXICITY
Oral rat LD50: 4260 mg/kg
n-Propyl Bromide; Bromure n-propylène (French); 1-Bromopropane;
n-Propilbromuro (Spanish); Propane, 1-Bromo-; 溴代正丙烷 (Chinese); Propyl bromide;
SMILES
CLASSIFICATION
Solvent
EXTRA NOTES
PHYSICAL AND CHEMICAL PROPERTIES
6 - 8
REFRACTIVE INDEX
25 C
EXTERNAL LINKS & GENERAL DESCRIPTION
Drug Information Portal (U.S. National Library of Medicine) - 1-BROMOPROPANE
PubChem Compound Summary - 1-BROMOPROPANE
http://www.cdc.gov/
1-Bromopropane (1-BP) (n-propyl bromide) is a solvent increasingly used as a
substitute for ozone-depleting chloro-fluorocarbons and similar regulated
compounds. 1-BP is used in vapor and immersion degreasing operations and other
manufacturing processes, and as a solvent in industries using aerosol-applied
adhesives. In some states, 1-BP is used as a solvent in dry cleaning because of
restrictions on use of perchloroethylene (tetrachloroethylene), a possible human
carcinogen (1). Published studies of workers exposed to 1-BP have raised
concerns about occupational health risks associated with exposure (2--5).
This report describes two cases involving workers exposed to 1-BP and diagnosed
with clinical manifestations of neurotoxicity. The cases, when coupled with
previously reported studies of workers exposed to 1-BP, illustrate potential
health risks of 1-BP exposure. Clinicians and public health professionals should
be alert to potential health effects among workers exposed to 1-BP, particularly
in dry cleaning and other workplaces where 1-BP use might be increasing, and
effective control methods to limit exposure to 1-BP should be implemented at
worksites.
Local:
1-Bromopropane, also known as n-propyl
bromide is a primary alkyl halide, with the formula CH3CH2CH2Br
. 2-Bromopropane
has bromine atom at the second position, also called isopropyl bromide.
The formula
is CH3CHBrCH3.
They are bromine atom position isomers. They are
colorless liquid, insoluble in water, but soluble in ethanol and ether.
They
are used as alkylating agents to introduce the alkyl
groups to form carbon-carbon bonds in
organic
synthesis. They are also used as intermediate to form alkylated amines
and alkylated metallic compounds. The end products
include pharmaceuticals, insecticides, quaternary ammonium compounds, flavours and fragrances.
They are also used as solvent for industrial cleaning (degreasing, metal processing and finishing, electronics, aerospace and aviation), aerosols, textiles, adhesives , inks and coatings.
APPEARANCE
ASSAY
99.0% max
FREE HBr
0.01% max
WATER
0.05% max
COLOR (APHA)
50 max
HAZARD OVERVIEW
OSHA Hazards:Flammable liquid, Irritant, Teratogen, Reproductive hazard
GHS
Danger
PICTOGRAMS
HAZARD STATEMENTS
H225
Highly flammable liquid and vapour.
H315 Causes skin irritation.
H319
Causes serious eye irritation.
H335 + H336 May cause respiratory
irritation, and drowsiness or dizziness.
H360 May damage fertility
or the unborn child.
H371 May cause damage to organs.
H412
Harmful to aquatic life with long lasting effects.
PRECAUTIONARY STATEMENTS
P201
Obtain special instructions before use.
P210 Keep away from heat/sparks/open
flames/hot surfaces. - No smoking.
P260 Do not breathe dust/
fume/ gas/ mist/ vapours/ spray.
P273 Avoid release to the environment.
P305
+ P351 + P338 IF IN EYES: Rinse cautiously with water for several
minutes. Remove contact lenses, if present and easy to do. Continue
rinsing.
P308 + P313 IF exposed or concerned: Get medical advice/
attention.
F
Highly Flammable
T
Toxic
RISK PHRASES
11
Highly Flammable
36/37/38
Irritating to eyes, respiratory system and skin
48/20
Harmful: danger of serious damage to health by
prolonged exposure through inhalation
60 May impair fertility
63
Possible risk of harm to the unborn child
67
Vapors may cause drowsiness and dizziness
SAFETY PHRASES
45
In case of accident or if you feel unwell, seek medical
advice immediately (show label where possible)
53
Avoid exposure - obtain special instruction before use