(2R,3S)-3-PHENYLISOSERINE HYDROCHLORIDE

PRODUCT IDENTIFICATION

CAS NO. 136561-53-0; 132201-32-2

(2R, 3S)-3-PHENYLISOSERINE

EINECS NO.  
FORMULA NH2CH(C6H5)CH(OH)COOH
MOL WT. 181.19

H.S. CODE

 

TOXICITY

 
SYNONYMS (2R,3S)-3-Phenyl-2-hydroxy-3-aminopropanoic acid HCl;

CLASSIFICATION

TAXANES /

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white powder
MELTING POINT  
BOILING POINT  
SPECIFIC GRAVITY  
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

 

NFPA RATINGS

 

AUTOIGNITION

 

FLASH POINT

 

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Chemically Isoserine is 2-hydroxy-3-aminopropanoic acid which is a isomeric compound with serine (2-Amino-3-hydroxypropionic acid), a nonessential amino acid. Isoserine moiety is found in isepamicin, an antiboitic against aerobic gram-negative bacilli and some gram-positive bacteria which are resist to aminoglycosides. It is also found in taxane derivatives which show one of the most promising antitumor activity. Natural taxol is found only in minute quantities in the bark. Semi-synthetic taxols are under research to meet the great demand. N-Benzoyl-(2R,3S)-3-phenylisoserine is an essential chiral side chain for the biological activity of taxol (paclitaxel), N-Carboxy-(2R,3S)-3-phenylisoserine is an ester moiety of  side chain of docetaxel.

SALES SPECIFICATION

APPEARANCE

white powder

PURITY

98.0% min

OPTICAL PURITY

98.0% min e.e
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26-36

PRICE INFORMATION

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