1-PIPERAZINECARBOXALDEHYDE

PRODUCT IDENTIFICATION

CAS NO. 7755-92-2

1-PIPERAZINECARBOXALDEHYDE

EINECS NO. 231-813-0
FORMULA C5H10N2O
MOL WT. 114.15

H.S. CODE

 

TOXICITY

 
SYNONYMS 1-Formylpiperazine; N-Formylpiperazine;
DERIVATION

 

CLASSIFICATION

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE clear to yellowish liquid
MELTING POINT  
BOILING POINT 94 - 97 C at 0.50 mmHg
SPECIFIC GRAVITY 1.1
SOLUBILITY IN WATER Soluble
pH  
VAPOR DENSITY

 

REFRACTIVE INDEX

1.5097 - 1.5117

NFPA RATINGS

Health: 1; Flammability: 1; Instability: 0

AUTOIGNITION

 

FLASH POINT

101 C

STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS

Piperazine is a heterocyclic compound containing four carbon atoms and two of nitrogen at 1,4 position ( als called 1,4-hexahydropyrazine). It is a deliquescent crystalline compound melting at 105 C; soluble in water, alcohol, glycerol, and glycols. It is used as a main ingredient of anthelmintics used to treat intestinal roundworms (ascariasis) infection in human and  poultry and to treat pinworms (enterobiasis; oxyuriasis) by altering cell membrane permeability and causing hyperpolarization of the membrane. Piperazine is a moiety in psychoactive drugs. Certain piperazine derivatives are suspected of ecstasy substitutes. Benzylpiperazine is bannaed in many countries. Benzylpiperazine  has been used as a anthelmintic (antiparastic effect). Nitrogen in piperazine ring plays an important role in biological research and drug manufacturing industry including the preparation of anthelmintic, antiallergenic, antibacterial, antihistamic, antiemetic and antimigraine agents. The piperazine ring and piperazine derivatives are important cyclic components in industrial field as raw materials for hardener of epoxy resins, corrosion inhibitors, insecticides, accelerators for rubber, urethane catalysts and antioxidants.

An example of 1-Amino-4-methylpiperazine application is to be used as an intermediate for pharmaceuticals ( Anti-tuberculostatic agent: Rifampicin).

SALES SPECIFICATION

APPEARANCE

white crystalline powder

ASSAY

99.0% min

REFRACTIVE INDEX

1.5097 - 1.5117
TRANSPORTATION
PACKING
 
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
Hazard Symbols: XI, Risk Phrases: 22-36/37/38, Safety Phrases: 26-36