| CAS
NO. |
4097-22-7 |
|
| EINECS NO. |
223-853-2 |
| FORMULA |
C10H13N5O2 |
| MOL
WT. |
235.25 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
6-Amino-9-(2',3'-dideosy-beta-D-glycero-pentofuranosyl) purine;
|
| 2',3'-Didesoxiadenosina;
2',3'-Didésoxyadénosine; Dideoxyadenosine;
6-Amino-9-(2',3'-dideosy-beta-D-glycero-pentofuranosyl) purine; ddA;
ddAdo; 6-Amino-9-
(2',3'-dideoxy-beta-D-glycero-pentofuranosyl)purine; Glycero-pentopyranosyladenine;
|
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white crystalline powder |
| MELTING POINT |
181 - 184 C |
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
soluble
(soluble in caustic soda) |
| pH |
|
| VAPOR DENSITY |
|
|
AUTOIGNITION
|
|
|
NFPA
RATINGS
|
Health: 1 Flammability: 0 Reactivity: 0 |
|
REFRACTIVE
INDEX
|
|
| FLASH
POINT |
|
| STABILITY |
Stable
under ordinary conditions |
|
GENERAL
DESCRIPTION AND APPLICATIONS
|
|
Dideoxynucleoside
is a synthetic nucleoside analogue which
lacks two hydroxyl groups on 2' and 3'
carbon. This modification prevents the formation of
phosphodiester linkages which are needed for the completion of nucleic acid
chains. Some 2',3'-dideoxynucleosides acts as a
chain-terminator of viral DNA by inhibiting the enzyme reverse
transcriptase. These compounds inhibit HIV replication and thus have antiretroviral activity
in the treatment of acquired immunodeficiency syndrome.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white crystalline powder |
|
ASSAY |
98.0 -
102.0% |
|
OPTICAL
ROTATION
|
-26°
~ -28° (c=1 in water)
|
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
Not
regulated |
| UN
NO. |
|
| OTHER
INFORMATION |
|
Hazard
Symbols: XI, Risk Phrases: 36/37/38,
Safety Phrases: 24/25-28A-37-45 |