2-HYDROXYPROPYL-beta-CYCLODEXTRIN

2-HYDROXYPROPYL-beta-CYCLODEXTRIN
PRODUCT IDENTIFICATION
CAS NO.	94035-02-6, 128446-35-5
EINECS NO.
FORMULA
MOL WT.	1380 - 1540
H.S. CODE
TOXICITY
SYNONYMS	beta-Hydroxypropylcycloamylose;
Hydroxypropylcycloheptaglucan; beta-Hydroxypropylcyclodextrin
DERIVATION
CLASSIFICATION
PHYSICAL AND CHEMICAL PROPERTIES
PHYSICAL STATE	white to off-white powder
MELTING POINT	Decomposes (> 260 C)
BOILING POINT
SPECIFIC GRAVITY
SOLUBILITY IN WATER	> 100g in100 ml
pH
VAPOR DENSITY
AUTOIGNITION
NFPA RATINGS	Health: 1 Flammability: 1 Reactivity: 0
REFRACTIVE INDEX
FLASH POINT
STABILITY	Stable under normal conditions.
GENERAL DESCRIPTION & APPLICATIONS
Cyclic structure oligomers of glucose ( called cyclodextrins) are obtained from the starch digests of the bacteria Bacillus macerans. The individual glucose units are connected by 1,4 bonds. The most abundant cyclodextrins are alpha, beta and gamma cyclodextrin which have 6,7 and 8 glucose units respectively. The interior cavity is hydrophobic and the outside of the molecule is hydrophilic. The enhanced of characteristics such as stability, aqueous solubility, and reduced volatility, can be modified through mainly propoxylation reactions of them. Potential applications of cyclodextrins include water-soluble pharmaceuticals, prolonged drug release, tabletting and herbicides and pesticides. Some examples of commercially available cyclodextrin, or derivatives thereof, are as follows: alpha-Cyclodextrin (CAS #: 10016-20-3) alpha-Cyclodextrin phosphate Sodium salt (CAS #: 199684-60-1) alpha-Cyclodextrin, sulfated Sodium salt Hydrate (CAS #: 699020-02-5) Hexakis (2,3,6-tri-O-acetyl)-alpha-cyclodextrin Hexakis (2,3,6-tri-O-methyl)-alpha-cyclodextrin Hexakis(2,3,6-tri-O-octyl)-alpha-cyclodextrin (CAS #: 140395-31-9) Hexakis-6-bromo-6-deoxy-alpha-cyclodextrin (CAS #: 53784-82-0) Hexakis-6-iodo-6-deoxy-alpha-cyclodextrin (CAS #: 131105-41-4) Hexakis (6-O-tertbutyl-dimethylsilyl)-alpha-cyclodextrin Butyl-alpha-cyclodextrin Succinyl-alpha-cyclodextrin (2-Hydroxypropyl)-alpha-cyclodextrin (CAS #: 128446-33-3) beta-Cyclodextrin (CAS #: 7585-39-9) beta-Cyclodextrin Hydrate (CAS #: 68168-23-0) beta-Cyclodextrin phosphate Sodium salt (CAS #: 199684-61-2) beta-Cyclodextrin sulfate beta-Cyclodextrin, sulfated Sodium salt (CAS #: 37191-69-8) Hydroxypropyl-beta-cyclodextrin (CAS #: 94035-02-6) 6-Monodeoxy-6-monoamino-beta-cyclodextrin 6-O-alpha-D-Glucosyl-beta-cyclodextrin (CAS #: 92517-02-7) 6-O-alpha-Maltosyl-beta-cyclodextrin Hydrate (CAS #: 104723-60-6) Heptakis-6-azido-6-deoxy-beta-cyclodextrin Heptakis(2,3-di-O-acetyl-6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 196398-66-0) Heptakis-(2,3-di-O-methyl-6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 201346-23-8) Heptakis(2,6-di-O-methyl)-beta-cyclodextrin (CAS #: 51166-71-3) Heptakis-(2,6-di-O-ethyl)-beta-cyclodextrin (CAS #: 111689-03-3) Heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin (CAS #: 55216-11-0) Heptakis(2,3,6-tri-O-acetyl)-beta-cyclodextrin Heptakis-(2,3,6-tri-O-benzoyl)-beta-cyclodextrin (CAS #: 23666-43-5) Heptakis-(2,3,6-tri-O-ethyl)-beta-cyclodextrin (CAS #: 111689-01-1) Heptakis-6-iodo-6-deoxy-beta-cyclodextrin (CAS #: 30754-23-5) Heptakis-6-(dimethyl-tert-butylsilyl)-6-deoxy-beta-cyclodextrin Heptakis-6-bromo-6-deoxy-beta-cyclodextrin Monoacetyl-beta-cyclodextrin Diacetyl-beta-cyclodextrin Triacetyl-beta-cyclodextrin (CAS #: 23739-88-0) Heptakis(3-O-acetyl-2,6-di-O-methyl)-beta-cyclodextrin (CAS #: 131889-29-7) Heptakis-(6-O-maltosyl)-beta-cyclodextrin Heptakis(6-O-sulfo)-beta-cyclodextrin Heptasodium salt (CAS #: 197587-31-8) Heptakis(6-O-t-butyldimethylsilyl-2,3-di-O-acetyl)-beta-cyclodextrin Succinyl-(2-hydroxypropyl)-beta-cyclodextrin (2,6-Di-O-)ethyl-beta-cyclodextrin (2-Carboxyethyl)-beta-cyclodextrin (2-Hydroxyethyl)-beta-cyclodextrin (CAS #: 128446-32-2) (2-Hydroxypropyl)-beta-cyclodextrin (CAS #: 128446-35-5) Butyl-beta-cyclodextrin Methyl-beta-cyclodextrin (CAS #: 128446-36-6) Silyl((6-O-tert-butyldimethyl)-2,3,-di-O-acetyl)-beta-cyclodextrin Succinyl-beta-cyclodextrin gamma-Cyclodextrin (CAS #: 17465-86-0) gamma-Cyclodextrin Hydrate (CAS #: 91464-90-3) gamma-Cyclodextrin phosphate Sodium salt (CAS #: 199684-62-3) Sulfopropyl-beta-cyclodextrin Carboxymethyl-gamma-cyclodextrin Octakis (2,3,6-tri-O-acetyl)-gamma-cyclodextrin Octakis (2,3,6-tri-O-methyl)-gamma-cyclodextrin Octakis (2,6-di-O-pentyl)-gamma-cyclodextrin Octakis-6-(dimethyl-tert-butylsilyl)-6-deoxy-gamma-cyclodextrin Octakis-6-bromo-6-deoxy-gamma-cyclodextrin (CAS #: 53784-84-2) Octakis-6-iodo-6-deoxy-gamma-cyclodextrin (CAS #: 168296-33-1) Octakis (6-O-t-butyldimethylsilyl)-gamma-cyclodextrin Succinyl-gamma-cyclodextrin (2-Hydroxypropyl)-gamma-cyclodextrin (CAS #: 128446-34-4) Acetyl-gamma-cyclodextrin Butyl-gamma-cyclodextrin
SALES SPECIFICATION
APPEARANCE	white to off-powder
PURITY	97.0% min
CLARITY	Clear and colorless in aqueous solution
SPECIFIC ROTATION	+127° ~ +132° (c=1 in H₂O on dry basis)
REDUCED COMPOUNDS	0.5% max
FREE CYCLODEXTRIN	0.1% max
SOLVENT RESIDUE	10 ppm max ( Methanol, methyl chloride)
ACIDITY	1.5% max
CHLORIDE	0.5% max
SULFATES	0.1% max
LOSS ON DRYING	5.0% max
MICROBIOLOGICAL	Standard Plate Count: 300 /g max. Yeast and Mold: 100 /g max. Salmonella: Negative / 25 g Coliform: Negative /g
HEAVY METALS	5ppm max
TRANSPORTATION
PACKING
HAZARD CLASS	Not regulated
UN NO.
OTHER INFORMATION
`Hazard Symbols: , Risk Phrases: , Safety Phrases: 24/25-28A-37-45`
GENERAL DESCRIPTION OF DEXTRIN
Dextrin is a polymeric carbohydrate which are formed during the hydrolysis of starch to sugars by heat, by acids, and by enzymes. (Maltose, sucrose and lactose are disaccharides of same empirical formula (C₁₂H₂₂O₁₁) but are isomers differs from in structure). Dextrin and starch have the general formula, -[C_x(H2O)_y)]_n- (y = x - 1), in which glucose units are joined to one another usually head-to-tail, but dextrin has a smaller and less complex molecule than starch. Dextrin is soluble in water but is precipitated by alcohol. It's chemical properties rely on the extent of the starch from which they are derived. Some dextrin react with iodine to give a blue color and is soluble in 25% alcohol (called amylodextrin); others a reddish-brown color and soluble in 55% alcohol (called erythrodextrin); and still others yield no color at all with iodine and soluble in 70% alcohol (called achrodextrin). It is also identified by dextrose equivalence (DE) which is a measure of reducing power compared to the standard of 100 (dextrose). The higher DE is the more extent of starch depolymerization. Maltodextrin is the product of low DE. Dextrin forms a strongly adherent paste when mixed with water and it is used as adhesive in the manufacture of gummed tapes, textiles and paper. It is used in producing nutritional products.