PRODUCT IDENTIFICATION

H.S. CODE

TOXICITY

CLASSIFICATION

EXTRA NOTES

PHYSICAL AND CHEMICAL PROPERTIES

57 - 61 C

REFRACTIVE INDEX

Stable under ordinary conditions.

EXTERNAL LINKS & GENERAL DESCRIPTION

Google Scholar Search

Drug Information Portal (U.S. National Library of Medicine) - 4-Benzyloxyindole

PubChem Compound Summary - 4-Benzyloxyindole

http://www.ebi.ac.uk/chebi/ -   4-Benzyloxyindole

http://www.ncbi.nlm.nih.gov/ -   4-Benzyloxyindole

http://www.sigmaaldrich.com/
Application: Reactant for regioselective synthesis of oxopyrrolidine analogs via iodine-catalyzed Markovnikov addition ·Reactant for preparation of indoles by Bartoli reductive cyclization as useful intermediates in medicinal chemistry research ·Reactant for synthesis of carbon-11-labeled 4-aryl-4H-chromenes as new PET agents for imaging of apoptosis in cancer·Reactant for preparation of HCV inhibitors·Reactant for preparation of indol-3-yl tetramethylcyclopropyl ketones as CB2 cannabinoid receptor ligands·Reactant for preparation of 4-aryl-4H-chromenes as apoptosis inducers

Local:
Indole, benzopyrrole, is a yellow crystalline powder with unpleasant aroma. It has the pyrrole ring (five-membered unsaturated ring structure composed of four carbon atoms and one nitrogen atom) which is fused to benzene ring. There are tautomerer called indolenine (unsubstituted 3H-indole) and structural isomer, isoindole. But they are unstable. Indole occurs in some plants or in coal tar, and is formed in the intestine during putrefaction and by certain cultures of bacteria. it is commercially synthesized from phenylhydrazine and pyruvic acid.  Indole structure is a motif in nature. Prominent examples include tryptophan (aromatic side chain amino acid), serotonin (neurotransmitter), auxin (plant growth hormone), and indigo (plant colorant). One more interesting point is all these compounds have functional branches at 3 position. Indole is used in perfumery and in preparing tryptophan, one of the 20 amino acids commonly found in animal proteins. It has important application in the industry of plant growth. It is used to prepare indoleacetic acid (auxin) and other plant growth substances which help the development of roots in plant. It is used to make selective herbicides. Indole and its derivatives are widely used in making perfumes, dyes and agrochemicals as well as in biologically active ingredients and clinical diagnostics.

APPEARANCE

ASSAY

99.0% min

MELTING POINT

57 - 61 C

HAZARD OVERVIEW

OSHA Hazards: Irritant

GHS

PICTOGRAMS

HAZARD STATEMENTS

H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338

RISK PHRASES

36/37/38

SAFETY PHRASES

26-36