5-(BENZYLTHIO)-1H-TETRAZOLE

PRODUCT IDENTIFICATION
CAS NO.

21871-47-6

5-(BENZYLTHIO)-1H-TETRAZOLE
EINECS NO.  
FORMULA C8H8N4S
MOL WT. 192.24

H.S. CODE

  

TOXICITY

  
SYNONYMS BTT; 5-Benzylmercaptotetrazole; 5-Benzylmercapto-1H-Tetrazole;
5-[(phenylmethyl)thio]-1H-Tetrazole;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white to off-white crystalline powder
MELTING POINT 136 -139 C
BOILING POINT  
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER  
pH  
VAPOR DENSITY

 

AUTOIGNITION

 

NFPA RATINGS

  

REFRACTIVE INDEX

 
FLASH POINT

 
STABILITY

Stable under ordinary conditions.

GENERAL DESCRIPTION & APPLICATIONS

Oligonucleotide is a short DNA (deoxyribonucleic acid) or RNA (ribonucleic acid) sequence, typically made up of a few (2–20) covalently linked nucleotides. In molecular genetics, a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe for detecting complementary DNA or RNA. Oligonucleotides are currently used for genomic,proteomic and drug discovery technologies. Tetrazole is the traditional oligonucleotide synthesis activato for good coupling efficiency and to decrease the coupling times. But there are disadvantages of tetrazole; crystallisation problem from solution and potential explosive property at room temperature. Some alternatives have been recommended;

  • 5-Ethylthio-1H-tetrazole [CAS RN: 89797-68-2]
  • 5-Methylthio-1H-tetrazole [CAS RN: 29515-99-9]
  • 5-Benzylthio-1H-tetrazole [CAS RN: 21871-47-6]
  • 5-Nitrophenyl-1H-tetrazole
  • 4,5-Dicyanoimidazole [CAS RN: 1122-28-7]
    		•
    SALES SPECIFICATION

    APPEARANCE

    		 white to off-white crystalline powder

    ASSAY

    99.0% min

    LOSS ON DRYING

    0.3% max

    MELTING POINT

    		 136 -139 C
    TRANSPORTATION
    PACKING
     
    HAZARD CLASS  
    UN NO.  
    REMARKS
    Hazard Symbols: XI, Risk Phrases: 36/37/38, Safety Phrases: 26