6-METHYLCOUMARIN

PRODUCT IDENTIFICATION
CAS NO. 92-48-8

6-METHYLCOUMARIN
EINECS NO. 202-158-8
FORMULA C10H8O2
MOL WT. 160.17

H.S. CODE

  

TOXICITY

  
SYNONYMS 6-methylcoumarinic anhydride; Toncarine;
6-MC; 6-methyl-1,2-benzopyrone; 6-methyl-2H-1-benzopyran-2-one; 6-methylbenzopyrone; 6-Methyl-2H-chromen-2-one;
DERIVATION

 

CLASSIFICATION

  

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE white crystalline powder
MELTING POINT 75 - 76 C
BOILING POINT

303 C
SPECIFIC GRAVITY

 
SOLUBILITY IN WATER Insoluble
pH  
VAPOR DENSITY

 
AUTOIGNITION  

REFRACTIVE INDEX

 
NFPA RATINGS Health: 1; Flammability: 0; Reactivity: 0
FLASH POINT

 
STABILITY Stable under normal conditions.

GENERAL DESCRIPTION & APPLICATIONS
Coumarin (anhydride of o-coumaric acid) is white, crystalline lactone, obtainable naturally from several plants, such as tonka bean, lavender, sweet clover grass, strawberries, and cinnamon, or produced synthetically from an amino acid, phenylalanine. It is the principle of dicumarol which inhibits the hepatic synthesis of the vitamin K–dependent coagulation factors. Coumarin derivatives are used widely as anticoagulants (such as warfarin, -OH group is attached at 4 position) for the treatment of disorders in which there is excessive or undesirable clotting, such as thrombophlebitis, pulmonary embolism, and certain cardiac conditions. Coumarin derivatives are also used as rodenticides due to the property of causing fatal hemorrhaging. Coumarin has the characteristic odour like that of vanilla beans. It is used for the preparation of perfumes, soaps, flavourings. The coumarin nucleus (benzo-2-pyrone) is derived cinnamic acid (phenylacrylic skeleton) in the biosynthesis. Accordingly, the hydroxy group attached to coumarin structure at 7 position is important in biosynthesis pathway. Umbelliferone (7-hydroxy coumarin), esculetin (6,7-Dihydroxycoumarin), scopoletin (7-hydroxy-6-methoxycoumarin) are the widespread coumarins in nature. Synthetic 7-hydroxy coumarins are used to absorb ultraviolet rays in sunscreen cosmetics and used in the synthesis of drugs especially anticancer. Scopoletin is used a peroxide or calcium signal during the oxidative burst. It is a acetylcholinesterase inhibitor.
SALES SPECIFICATION

APPEARANCE

 white crystalline powder
ASSAY

99.0% min
MELTING POINT

75 - 76 C

SULFATED ASH

0.2% max

LOSS ON DRYING

0.5% max
TRANSPORTATION
PACKING  
HAZARD CLASS  
UN NO.  
OTHER INFORMATION
FEMA No.: 2699
Hazard Symbols: XN, Risk Phrases: 20/21/22-40-42/43, Safety Phrases: 7-36-45